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(New page: ==Your Heading Here (maybe something like 'Structure')== <StructureSection load='1acj' size='350' side='right' caption='Escherichia coli reca protein-bound DNA (PDB entry 1acj)' scene=...)
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Revision as of 18:58, 18 June 2017
Your Heading Here (maybe something like 'Structure')
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1ACJ* shows the crystal structure of Torpedo californica acetylcholinesterase (TcAChE) complexed with tacrine.
Tacrine was the first cholinesterase inhibitor approved for the treatment of Alzheimer's disease.
Tacrine’s ringed structure is stacked between the aromatic rings of Trp84 and Phe330.
- Harel et al Silman & Sussman (1993) "Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase" PNAS, 90, 9031-5.
