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Sandbox 7784
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Tacrine was the first cholinesterase inhibitor approved for the treatment of Alzheimer's disease. | Tacrine was the first cholinesterase inhibitor approved for the treatment of Alzheimer's disease. | ||
| - | Tacrine’s ringed structure is stacked between the <scene name='76/761691/Tacrine/2'>aromatic rings of Trp84 and Phe330</scene>. | + | Tacrine’s ringed structure is stacked between the <scene name='76/761691/Tacrine/2'>aromatic rings of Trp84 and Phe330</scene>.<ref>PMID:415649</ref> |
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*Harel et al Silman & Sussman (1993) "Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase" PNAS, 90, 9031-5. | *Harel et al Silman & Sussman (1993) "Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase" PNAS, 90, 9031-5. | ||
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</StructureSection> | </StructureSection> | ||
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Revision as of 19:10, 18 June 2017
Your Heading Here (maybe something like 'Structure')
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References
- ↑ Daniel TM, Anderson PA. The isolation by immunoabsorbent affinity chromatography and physicochemical characterization of Mycobacterium tuberculosis antigen 5. Am Rev Respir Dis. 1978 Mar;117(3):533-9. PMID:415649 doi:http://dx.doi.org/10.1164/arrd.1978.117.3.533
