Sandbox 12005

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Revision as of 09:27, 19 June 2017

to the rescue.

1ACJ* shows the crystal structure of Torpedo californica acetylcholinesterase (TcAChE) complexed with tacrine.

Tacrine was the first cholinesterase inhibitor approved for the treatment of Alzheimer's disease.

Tacrine’s ringed structure is stacked between the aromatic rings of Trp84 and Phe330^[1].

↑ Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I, Sussman JL. Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase. Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9031-5. PMID:8415649

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 ==Your Heading Here (maybe something like 'Structure')==
-<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
+<StructureSection load='1acj' size='340' side='right' caption='Acetylcholinesterase with Tacrine bound to it'>
-This is a default text for your page '''Sandbox 12005'''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
+ to the rescue.
-You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
 == Function ==
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 == Structural highlights ==
-This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
+ACJ* shows the crystal structure of Torpedo californica acetylcholinesterase (TcAChE) complexed with tacrine.
+Tacrine was the first cholinesterase inhibitor approved for the treatment of Alzheimer's disease.
+Tacrine’s ringed structure is stacked between the aromatic rings of Trp84 and Phe330<ref>PMID:8415649</ref>.
 </StructureSection>
 == References ==
 <references/>