Interferon receptor
From Proteopedia
(Difference between revisions)
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| - | <StructureSection load='3s9d' size='350' side='right' caption='Structure of interferon α/β receptor β chain ectodomain ( | + | <StructureSection load='3s9d' size='350' side='right' caption='Structure of interferon α/β receptor β chain ectodomain (yellow) complex with interferon-α 2 (pink) and Cl- ion (green) (PDB entry [[3s9d]])' scene=''> |
== Function == | == Function == | ||
'''Interferon receptor''' (IFNR) is a cell surface receptor which binds interferon.<br /> | '''Interferon receptor''' (IFNR) is a cell surface receptor which binds interferon.<br /> | ||
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**[[1fg9]], [[1fyh]] – hINFGR1 extracellular domain + interferon-γ <br /> | **[[1fg9]], [[1fyh]] – hINFGR1 extracellular domain + interferon-γ <br /> | ||
**[[4eq2]], [[4eq3]] – INFGR1 α chain - chicken <br /> | **[[4eq2]], [[4eq3]] – INFGR1 α chain - chicken <br /> | ||
| + | **[[5eh1]] – hINFGR2 extracellular domain <br /> | ||
*Interferon δ receptor | *Interferon δ receptor | ||
**[[3og4]], [[3og6]] – hINFDR1 extracellular domain + interleukin-29 <br /> | **[[3og4]], [[3og6]] – hINFDR1 extracellular domain + interleukin-29 <br /> | ||
| + | **[[5t5w]] – hINFDR1 extracellular domain + interleukin-10 receptor + interferon-δ 3 <br /> | ||
| + | **[[5t5w]], [[5ixd]] – hINFDR1 residues 260-307 + JAK1 <br /> | ||
}} | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 09:50, 20 June 2017
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3D structures of interferon receptor
Updated on 20-June-2017
References
- ↑ Uze G, Schreiber G, Piehler J, Pellegrini S. The receptor of the type I interferon family. Curr Top Microbiol Immunol. 2007;316:71-95. PMID:17969444
- ↑ Pestka S, Kotenko SV, Muthukumaran G, Izotova LS, Cook JR, Garotta G. The interferon gamma (IFN-gamma) receptor: a paradigm for the multichain cytokine receptor. Cytokine Growth Factor Rev. 1997 Sep;8(3):189-206. PMID:9462485
- ↑ Lefevre F, Guillomot M, D'Andrea S, Battegay S, La Bonnardiere C. Interferon-delta: the first member of a novel type I interferon family. Biochimie. 1998 Aug-Sep;80(8-9):779-88. PMID:9865499
- ↑ . PMID:16451483
- ↑ Santiago-Raber ML, Baccala R, Haraldsson KM, Choubey D, Stewart TA, Kono DH, Theofilopoulos AN. Type-I interferon receptor deficiency reduces lupus-like disease in NZB mice. J Exp Med. 2003 Mar 17;197(6):777-88. PMID:12642605 doi:http://dx.doi.org/10.1084/jem.20021996
- ↑ Jouanguy E, Lamhamedi-Cherradi S, Lammas D, Dorman SE, Fondaneche MC, Dupuis S, Doffinger R, Altare F, Girdlestone J, Emile JF, Ducoulombier H, Edgar D, Clarke J, Oxelius VA, Brai M, Novelli V, Heyne K, Fischer A, Holland SM, Kumararatne DS, Schreiber RD, Casanova JL. A human IFNGR1 small deletion hotspot associated with dominant susceptibility to mycobacterial infection. Nat Genet. 1999 Apr;21(4):370-8. PMID:10192386 doi:http://dx.doi.org/10.1038/7701
