Interleukin receptor
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | |||
<StructureSection load='2b5i' size='340' side='right' caption='Glycosylated interleukin-2 receptor α (yellow), β (green), γ (pink) chains complex with interleukin-2 (grey), [[2b5i]]' scene=''> | <StructureSection load='2b5i' size='340' side='right' caption='Glycosylated interleukin-2 receptor α (yellow), β (green), γ (pink) chains complex with interleukin-2 (grey), [[2b5i]]' scene=''> | ||
'''Interleukin receptors''' (ILR) are cytokine receptor which are classified into type I, type II and others. '''ILR type I''' are cell surface receptors which recognize cytokines with four α-helical strands. '''ILR type II''' are similar to type I but lack the former’s signature sequence: WXSWS. Interleukin-1 receptor belongs to the ILR of immunoglobulin family. IL1R contains two types. Type I (IL1R1) binds interleukin-1 (IL1) transmitting its inflammatory effect. Interleukin-1 receptor type II (IL1R2) suppresses IL1 activity. Another suppressor of IL1R activity is the interleukin-1 receptor antagonist (IL1R1A). | '''Interleukin receptors''' (ILR) are cytokine receptor which are classified into type I, type II and others. '''ILR type I''' are cell surface receptors which recognize cytokines with four α-helical strands. '''ILR type II''' are similar to type I but lack the former’s signature sequence: WXSWS. Interleukin-1 receptor belongs to the ILR of immunoglobulin family. IL1R contains two types. Type I (IL1R1) binds interleukin-1 (IL1) transmitting its inflammatory effect. Interleukin-1 receptor type II (IL1R2) suppresses IL1 activity. Another suppressor of IL1R activity is the interleukin-1 receptor antagonist (IL1R1A). | ||
| Line 14: | Line 13: | ||
**[[1z92]] – hIL2R α subunit + IL2 - human<br /> | **[[1z92]] – hIL2R α subunit + IL2 - human<br /> | ||
| + | **[[5m5e]] - hIL2R β subunit + IL2 + cytokine receptor common subunit γ<br /> | ||
**[[2b5i]] - hIL2R α+β+γ subunits + IL2<br /> | **[[2b5i]] - hIL2R α+β+γ subunits + IL2<br /> | ||
**[[3qaz]] - hIL2R β+γ subunits + IL2<br /> | **[[3qaz]] - hIL2R β+γ subunits + IL2<br /> | ||
| Line 53: | Line 53: | ||
**[[3di2]], [[3di3]] – hIL7R α (mutant) subunit + IL7 (mutant)<br /> | **[[3di2]], [[3di3]] – hIL7R α (mutant) subunit + IL7 (mutant)<br /> | ||
**[[4nn5]], [[4nn6]], [[4nn7]] - mIL7R α subunit + thymic stromal lymphopoietin + cytokine receptor-like factor 2<br /> | **[[4nn5]], [[4nn6]], [[4nn7]] - mIL7R α subunit + thymic stromal lymphopoietin + cytokine receptor-like factor 2<br /> | ||
| + | |||
| + | *Interleukin-10 receptor | ||
| + | |||
| + | **[[5t5w]] - hIL10 (mutant) + interferon λ receptor 21 + interferon λ-3 subunit <br /> | ||
*Interleukin-13 receptor | *Interleukin-13 receptor | ||
| Line 58: | Line 62: | ||
**[[3lb6]] - hIL13R α2 (mutant) subunit + IL13<br /> | **[[3lb6]] - hIL13R α2 (mutant) subunit + IL13<br /> | ||
**[[4hwb]] - hIL13R α1 subunit + antibody<br /> | **[[4hwb]] - hIL13R α1 subunit + antibody<br /> | ||
| + | **[[5e4e]] - hIL13R α1 subunit + IL4R α subunit + IL13<br /> | ||
*Interleukin-15 receptor | *Interleukin-15 receptor | ||
Revision as of 08:15, 22 June 2017
| |||||||||||
3D structures of interleukin receptor
Updated on 22-June-2017
