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Tissue factor

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<StructureSection load='1j9c' size='340' side='right' caption='Structure of human tissue factor (green) complex with coagulation factor VIIa heavy chain (magenta) and light chain (aqua) and Ca+2 ion (green) (PDB code [[2aer]]).' scene='59/595166/Cv/1'>
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<StructureSection load='1j9c' size='340' side='right' caption='Structure of human tissue factor (green) complex with coagulation factor VIIa heavy chain (magenta) and light chain (deep sky blue) and Ca+2 ion (green) (PDB code [[1j9c]]).' scene='59/595166/Cv/1'>
== Function ==
== Function ==
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== Relevance ==
== Relevance ==
TF expression by cardiac myocytes is important to maintain heart hemostasis under normal and pathologic conditions<ref>PMID:17663739</ref>.
TF expression by cardiac myocytes is important to maintain heart hemostasis under normal and pathologic conditions<ref>PMID:17663739</ref>.
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*<scene name='59/595166/Cv/2'>Human tissue factor complex with coagulation factor VIIa heavy chain, light chain and Ca+2 ion</scene> (PDB code [[1j9c]]).
</StructureSection>
</StructureSection>

Revision as of 08:55, 22 June 2017

Structure of human tissue factor (green) complex with coagulation factor VIIa heavy chain (magenta) and light chain (deep sky blue) and Ca+2 ion (green) (PDB code 1j9c).

Drag the structure with the mouse to rotate

3D structures of tissue factor

Updated on 22-June-2017

References

  1. ↑ Chen VM, Hogg PJ. Encryption and decryption of tissue factor. J Thromb Haemost. 2013 Jun;11 Suppl 1:277-84. doi: 10.1111/jth.12228. PMID:23809131 doi:http://dx.doi.org/10.1111/jth.12228
  2. ↑ Poon RT, Lau CP, Ho JW, Yu WC, Fan ST, Wong J. Tissue factor expression correlates with tumor angiogenesis and invasiveness in human hepatocellular carcinoma. Clin Cancer Res. 2003 Nov 1;9(14):5339-45. PMID:14614019
  3. ↑ Pawlinski R, Tencati M, Holscher T, Pedersen B, Voet T, Tilley RE, Marynen P, Mackman N. Role of cardiac myocyte tissue factor in heart hemostasis. J Thromb Haemost. 2007 Aug;5(8):1693-700. PMID:17663739 doi:http://dx.doi.org/10.1111/j.1538-7836.2007.02649.x

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Michal Harel, Joel L. Sussman, Alexander Berchansky

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