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GP1 of Lassa Virus

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== Histidine Triad==
== Histidine Triad==
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Attached to this structure is a unique triad of histidines. This particular histidine triad is highly conserved among Old World arenaviruses<ref>DOI 10.1128/JVI.00651-15</ref>. Forming on the LAMP1-binding site(insert scene), the histidine triad provides a molecular mechanism for the pH-dependent receptor switching. The histidine triad is shown to be necessary for interaction with LAMP1.
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Attached to this structure is a unique triad of histidines. This particular histidine triad is highly conserved among Old World arenaviruses<ref>DOI 10.1128/JVI.00651-15</ref>. Forming on the [[LAMP1]]-binding site(insert scene), the histidine triad provides a molecular mechanism for the pH-dependent receptor switching. The histidine triad is shown to be necessary for interaction with LAMP1.

Revision as of 09:24, 22 June 2017

4ZJF structure

Drag the structure with the mouse to rotate

References

You may include any references to papers as in: the use of JSmol in Proteopedia [2] or to the article describing Jmol [3] to the rescue.

  1. ↑ Cohen-Dvashi H, Cohen N, Israeli H, Diskin R. Molecular mechanism for LAMP1 recognition by Lassa Virus. J Virol. 2015 May 13. pii: JVI.00651-15. PMID:25972533 doi:http://dx.doi.org/10.1128/JVI.00651-15
  2. ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
  3. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644

Proteopedia Page Contributors and Editors (what is this?)

Rebecca Holstein, Michal Harel

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