Metabotropic glutamate receptor
From Proteopedia
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**[[4xas]], [[4xaq]] – hMGluR2 LBD + agonist<br /> | **[[4xas]], [[4xaq]] – hMGluR2 LBD + agonist<br /> | ||
| + | **[[5kzq]], [[5kzn]] – hMGluR2 LBD + antagonist<br /> | ||
| + | **[[5cni]] – hMGluR2 LBD + Glu <br /> | ||
| + | **[[5cnj]] – hMGluR2 LBD + Glu analog<br /> | ||
*Metabotropic glutamate receptor 3 | *Metabotropic glutamate receptor 3 | ||
| + | **[[5cnk]] – hMGluR3 LBD + Glu <br /> | ||
**[[2e4u]] – rMGluR3 LBD (mutant) + Glu<br /> | **[[2e4u]] – rMGluR3 LBD (mutant) + Glu<br /> | ||
**[[2e4v]], [[2e4w]], [[2e4x]], [[2e4y]], [[2e4z]] - rMGluR3 LBD (mutant) + agonist<br /> | **[[2e4v]], [[2e4w]], [[2e4x]], [[2e4y]], [[2e4z]] - rMGluR3 LBD (mutant) + agonist<br /> | ||
**[[3sm9]] - hMGluR3 + antagonist<br /> | **[[3sm9]] - hMGluR3 + antagonist<br /> | ||
**[[4xar]] – hMGluR3 LBD + agonist<br /> | **[[4xar]] – hMGluR3 LBD + agonist<br /> | ||
| + | **[[5cnm]] – hMGluR3 LBD + Glu analog<br /> | ||
*Metabotropic glutamate receptor 5 | *Metabotropic glutamate receptor 5 | ||
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*Metabotropic glutamate receptor 7 | *Metabotropic glutamate receptor 7 | ||
| + | **[[5c5c]] – hMGluR7 LBD (mutant)<br /> | ||
**[[3mq4]] – hMGluR7 LBD + antagonist<br /> | **[[3mq4]] – hMGluR7 LBD + antagonist<br /> | ||
}} | }} | ||
Revision as of 06:42, 26 June 2017
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3D structures of metabotropic glutamate receptor
Updated on 26-June-2017
See Also
Membrane Channels & Pumps
Ionotropic_Glutamate_Receptors
Alzheimer's Disease
References
- ↑ Traynelis SF, Wollmuth LP, McBain CJ, Menniti FS, Vance KM, Ogden KK, Hansen KB, Yuan H, Myers SJ, Dingledine R. Glutamate receptor ion channels: structure, regulation, and function. Pharmacol Rev. 2010 Sep;62(3):405-96. doi: 10.1124/pr.109.002451. PMID:20716669 doi:http://dx.doi.org/10.1124/pr.109.002451
- ↑ Johnson KA, Conn PJ, Niswender CM. Glutamate receptors as therapeutic targets for Parkinson's disease. CNS Neurol Disord Drug Targets. 2009 Dec;8(6):475-91. PMID:19702565
- ↑ Niswender CM, Conn PJ. Metabotropic glutamate receptors: physiology, pharmacology, and disease. Annu Rev Pharmacol Toxicol. 2010;50:295-322. doi:, 10.1146/annurev.pharmtox.011008.145533. PMID:20055706 doi:http://dx.doi.org/10.1146/annurev.pharmtox.011008.145533
- ↑ Kunishima N, Shimada Y, Tsuji Y, Sato T, Yamamoto M, Kumasaka T, Nakanishi S, Jingami H, Morikawa K. Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor. Nature. 2000 Oct 26;407(6807):971-7. PMID:11069170 doi:10.1038/35039564
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