Kallikrein

From Proteopedia

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Line 34: Line 34:
**[[4nfe]] – hKLK + inhibitor - human <br />
**[[4nfe]] – hKLK + inhibitor - human <br />
 +
**[[4nff]] – hKLK + PPACK <br />
*Kallikrein 4
*Kallikrein 4
Line 58: Line 59:
**[[3bsq]] – hKLK <br />
**[[3bsq]] – hKLK <br />
**[[2qxg]], [[2qxh]], [[2qxi]], [[2qxj]] – hKLK + chymotriptic determinant <br />
**[[2qxg]], [[2qxh]], [[2qxi]], [[2qxj]] – hKLK + chymotriptic determinant <br />
 +
**[[5fah]] – hKLK + inhibitor<br />
 +
 +
*Kallikrein 10
 +
 +
**[[5lpf]] – hKLK <br />
 +
**[[5lpe]] – hKLK + Zn<br />
*Kallikrein 13
*Kallikrein 13
Line 65: Line 72:
*Plasma kallikrein
*Plasma kallikrein
-
**[[2anw]], [[2any]] – hKLK catalytic domain (mutant) + benzamidine <br />
+
**[[4ogx]], [[4ogy]] – hKLK light chain (mutant) + antibody <br />
-
**[[4ogx]], [[4ogy]] – hKLK catalytic domain (mutant) + antibody <br />
+
**[[5f8z]] – hKLK light chain (mutant) + Pkalin-1 <br />
 +
**[[5f8t]] – hKLK light chain (mutant) + Pkalin-2 <br />
 +
**[[5f8x]] – hKLK light chain (mutant) + Pkalin-3 <br />
 +
**[[5tjx]], [[2anw]], [[2any]] – hKLK light chain (mutant) + inhibitor <br />
*Tissue kallikrein (KLK 1)
*Tissue kallikrein (KLK 1)

Revision as of 10:06, 27 June 2017

Structure of human kallikrein 4 complex with p-aminobenzamidine and Zn+2 ion (grey) (PDB code 2bdh)

Drag the structure with the mouse to rotate

3D Structures of kallikrein

Updated on 27-June-2017

References

  1. Bryant JW, Shariat-Madar Z. Human plasma kallikrein-kinin system: physiological and biochemical parameters. Cardiovasc Hematol Agents Med Chem. 2009 Jul;7(3):234-50. PMID:19689262
  2. Feener EP. Plasma kallikrein and diabetic macular edema. Curr Diab Rep. 2010 Aug;10(4):270-5. doi: 10.1007/s11892-010-0127-1. PMID:20535647 doi:http://dx.doi.org/10.1007/s11892-010-0127-1
  3. Pampalakis G, Sotiropoulou G. Multiple mechanisms underlie the aberrant expression of the human kallikrein 6 gene in breast cancer. Biol Chem. 2006 Jun;387(6):773-82. PMID:16800739 doi:http://dx.doi.org/10.1515/BC.2006.097
  4. Debela M, Magdolen V, Grimminger V, Sommerhoff C, Messerschmidt A, Huber R, Friedrich R, Bode W, Goettig P. Crystal structures of human tissue kallikrein 4: activity modulation by a specific zinc binding site. J Mol Biol. 2006 Oct 6;362(5):1094-107. Epub 2006 Aug 3. PMID:16950394 doi:10.1016/j.jmb.2006.08.003

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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