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Kelch-like protein

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Line 36: Line 36:
*Kelch-like protein 3
*Kelch-like protein 3
-
**[[4chb]], [[4ch9]] – hKLHL3 Kelch domain + serine/threonine protein kinas WNK4 peptide <br />
+
**[[4chb]], [[4ch9]], [[5nkp]] – hKLHL3 Kelch domain + serine/threonine protein kinas WNK4 peptide <br />
**[[4hxi]] – hKLHL3 BTB-BACK domain (mutant) + cullin-3 N terminal <br />
**[[4hxi]] – hKLHL3 BTB-BACK domain (mutant) + cullin-3 N terminal <br />
Line 84: Line 84:
**[[3wn7]] – mKeap1 Kelch domain + NRF2 residues 17-51 <br />
**[[3wn7]] – mKeap1 Kelch domain + NRF2 residues 17-51 <br />
**[[4ifl]], [[2flu]], [[3zgc]] – hKeap1 Kelch domain + NRF2 Neh2 peptide <br />
**[[4ifl]], [[2flu]], [[3zgc]] – hKeap1 Kelch domain + NRF2 Neh2 peptide <br />
 +
**[[5nlb]] – hKeap1 BTB+ 3-BOX domains + CUL-3 <br />
 +
**[[5f72]] – hKLHL1 Kelch domain + antibody <br />
 +
**[[5x54]] – hKLHL1 Kelch domain + tetrapeptide <br />
*Keap1 complex with small molecule
*Keap1 complex with small molecule
Line 90: Line 93:
**[[4ifn]] – hKeap1 Kelch domain + quinoline derivative <br />
**[[4ifn]] – hKeap1 Kelch domain + quinoline derivative <br />
**[[4l7b]], [[4l7c]], [[4l7d]] [[4n1b]] – hKeap1 Kelch domain (mutant) + quinoline derivative <br />
**[[4l7b]], [[4l7c]], [[4l7d]] [[4n1b]] – hKeap1 Kelch domain (mutant) + quinoline derivative <br />
-
**[[4in4]] – hKeap1 Kelch domain + inhibitor <br />
+
**[[4in4]], [[4zy3]], [[5fnq]], [[5fnr]], [[5fns]], [[5fnt]], [[5fnu]], [[5fzj]], [[5fzn]] – hKeap1 Kelch domain + inhibitor <br />
-
**[[4iqk]] – hKeap1 Kelch domain (mutant) + inhibitor <br />
+
**[[4iqk]], [[4n1b]] – hKeap1 Kelch domain (mutant) + inhibitor <br />
**[[4cxt]] – hKeap1 BTB domain (mutant) + antagonist<br />
**[[4cxt]] – hKeap1 BTB domain (mutant) + antagonist<br />
 +
**[[5dad]], [[5daf]] – hKeap1 BTB domain + activator <br />
}}
}}

Revision as of 08:28, 28 June 2017

Human Kelch-like protein 1 (Keap1) Kelch domain (cyan) complex with NRF2 Neh2 peptide (green) and sulfate (PDB code 1x2r)

Drag the structure with the mouse to rotate

3D Structures of Kelch-like protein

Updated on 28-June-2017


References

  1. ↑ Dhanoa BS, Cogliati T, Satish AG, Bruford EA, Friedman JS. Update on the Kelch-like (KLHL) gene family. Hum Genomics. 2013 May 15;7:13. doi: 10.1186/1479-7364-7-13. PMID:23676014 doi:http://dx.doi.org/10.1186/1479-7364-7-13
  2. ↑ Padmanabhan B, Tong KI, Ohta T, Nakamura Y, Scharlock M, Ohtsuji M, Kang MI, Kobayashi A, Yokoyama S, Yamamoto M. Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer. Mol Cell. 2006 Mar 3;21(5):689-700. PMID:16507366 doi:10.1016/j.molcel.2006.01.013

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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