Ketohexokinase
From Proteopedia
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Human <scene name='48/484861/Cv/3'>KHK inhibitor interacts with the 2 monomers</scene><ref>PMID:24900346</ref>. Water molecule shown as red sphere. | Human <scene name='48/484861/Cv/3'>KHK inhibitor interacts with the 2 monomers</scene><ref>PMID:24900346</ref>. Water molecule shown as red sphere. | ||
</StructureSection> | </StructureSection> | ||
| - | ==3D | + | ==3D structures of ketohexokinase== |
[[2hlz]], [[2hqq]], [[3b3l]] – hKHK – human<br /> | [[2hlz]], [[2hqq]], [[3b3l]] – hKHK – human<br /> | ||
Revision as of 09:21, 28 June 2017
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3D structures of ketohexokinase
2hlz, 2hqq, 3b3l – hKHK – human
2hw1, 3nbv – hKHK + AMPPNP + fructose
3nbw – hKHK + pyrazole derivative
3nc2, 3nc9, 3nca, 3ro4, 3q92, 3qa2, 3qai – hKHK + inhibitor
References
- ↑ Bais R, James HM, Rofe AM, Conyers RA. The purification and properties of human liver ketohexokinase. A role for ketohexokinase and fructose-bisphosphate aldolase in the metabolic production of oxalate from xylitol. Biochem J. 1985 Aug 15;230(1):53-60. PMID:2996495
- ↑ Asipu A, Hayward BE, O'Reilly J, Bonthron DT. Properties of normal and mutant recombinant human ketohexokinases and implications for the pathogenesis of essential fructosuria. Diabetes. 2003 Sep;52(9):2426-32. PMID:12941785
- ↑ Maryanoff BE, O'Neill JC, McComsey DF, Yabut SC, Luci DK, Jordan AD Jr, Masucci JA, Jones WJ, Abad MC, Gibbs AC, Petrounia I. Inhibitors of Ketohexokinase: Discovery of Pyrimidinopyrimidines with Specific Substitution that Complements the ATP-Binding Site. ACS Med Chem Lett. 2011 Apr 18;2(7):538-43. doi: 10.1021/ml200070g. eCollection, 2011 Jul 14. PMID:24900346 doi:http://dx.doi.org/10.1021/ml200070g
