MEP cytidylyltransferase

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Line 28: Line 28:
**[[4myb]] – MEPCT – ''Francisella tularensis''<br />
**[[4myb]] – MEPCT – ''Francisella tularensis''<br />
**[[4nai]] – AtMEPCT CT domain – ''Arabidopsis thaliana''<br />
**[[4nai]] – AtMEPCT CT domain – ''Arabidopsis thaliana''<br />
 +
**[[5mrn]], [[5mrq]] – AtMEPCT CT domain (mutant) <br />
**[[4ys8]] – BtMEPCT – ''Burkholderia thailandensis'' <br />
**[[4ys8]] – BtMEPCT – ''Burkholderia thailandensis'' <br />
 +
**[[5ddt]], [[5ddv]] – BsMEPCT – ''Bacillus subtilis'' <br />
*MEP cytidylyltransferase complex with cytidine
*MEP cytidylyltransferase complex with cytidine
Line 41: Line 43:
**[[3q80]] – MtMEPCT + CDP-ME <br />
**[[3q80]] – MtMEPCT + CDP-ME <br />
**[[4zdq]] – BtMEPCT + CTP <br />
**[[4zdq]] – BtMEPCT + CTP <br />
 +
**[[5hs2]] – BsMEPCT + CTP <br />
*MEP cytidylyltransferase other complexes
*MEP cytidylyltransferase other complexes
Line 47: Line 50:
**[[3okr]] – MtMEPCT + peptide <br />
**[[3okr]] – MtMEPCT + peptide <br />
**[[4nak]], [[4nal]], [[4nan]] – AtMEPCT CT domain (mutant) + pseudilin derivative<br />
**[[4nak]], [[4nal]], [[4nan]] – AtMEPCT CT domain (mutant) + pseudilin derivative<br />
 +
**[[5mro]], [[5mrp]] – AtMEPCT CT domain (mutant) + pyrimidine derivative<br />
 +
**[[5mrm]] – AtMEPCT CT domain (mutant) + isoxazole<br />
**[[2vsi]] – SpMEPCT + pyrimidine derivative <br />
**[[2vsi]] – SpMEPCT + pyrimidine derivative <br />
}}
}}

Revision as of 07:19, 20 July 2017

Structure of E. coli MEP cytidylyltransferase complex with CTP, Mg+2 (small light green) and Ca+2 (large green) (PDB code 1i52).

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3D structures of MEP cytidylyltransferase

Updated on 20-July-2017

References

  1. Friedrich R, Fuentes-Prior P, Ong E, Coombs G, Hunter M, Oehler R, Pierson D, Gonzalez R, Huber R, Bode W, Madison EL. Catalytic domain structures of MT-SP1/matriptase, a matrix-degrading transmembrane serine proteinase. J Biol Chem. 2002 Jan 18;277(3):2160-8. Epub 2001 Nov 5. PMID:11696548 doi:10.1074/jbc.M109830200
  2. Tsang A, Seidle H, Jawaid S, Zhou W, Smith C, Couch RD. Francisella tularensis 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase: kinetic characterization and phosphoregulation. PLoS One. 2011;6(6):e20884. doi: 10.1371/journal.pone.0020884. Epub 2011 Jun 9. PMID:21694781 doi:http://dx.doi.org/10.1371/journal.pone.0020884
  3. Richard SB, Bowman ME, Kwiatkowski W, Kang I, Chow C, Lillo AM, Cane DE, Noel JP. Structure of 4-diphosphocytidyl-2-C- methylerythritol synthetase involved in mevalonate- independent isoprenoid biosynthesis. Nat Struct Biol. 2001 Jul;8(7):641-8. PMID:11427897 doi:10.1038/89691

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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