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Mitogen-activated protein kinase
From Proteopedia
(Difference between revisions)
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*MAPK1 | *MAPK1 | ||
**[[4g6n]], [[4g6o]], [[4gsb]] – hMAPK1 - human<br /> | **[[4g6n]], [[4g6o]], [[4gsb]] – hMAPK1 - human<br /> | ||
| - | **[[3i5z]], [[3i60]], [[3w55]], [[2ojg]], [[2oji]], [[2ojj]], [[1wzy]], [[1tvo]], [[3sa0]], [[4fux]], [[4fuy]], [[4fv0]], [[4fv1]], [[4fv2]], [[4fv3]], [[4fv4]], [[4fv5]], [[4fv6]], [[4fv7]], [[4fv8]], [[4fv9]] – hMAPK1+inhibitor - human<br /> | + | **[[3i5z]], [[3i60]], [[3w55]], [[2ojg]], [[2oji]], [[2ojj]], [[1wzy]], [[1tvo]], [[3sa0]], [[4fux]], [[4fuy]], [[4fv0]], [[4fv1]], [[4fv2]], [[4fv3]], [[4fv4]], [[4fv5]], [[4fv6]], [[4fv7]], [[4fv8]], [[4fv9]], [[4n4s]], [[4o6e]], [[4qp1]], [[4qp2]], [[4qp3]], [[4qp4]], [[4qp6]], [[4qp7]], [[4qp8]], [[4qp9]] [[4qpa]], [[4qta]], [[4qte]], [[4xj0]], [[4xne]], [[4xoy]], [[4xoz]], [[4xp0]], [[4xp2]], [[4xp3]], [[4xrj]], [[4xrl]], [[4zzm]], [[4zzn]], [[4zzo]], [[5bue]], [[5bui]], [[5buj]], [[5bvd]], [[5bve]], [[5bvf]], [[5hd4]], [[5hd7]], [[5k4i]], [[5ke0]], [[5lcj]], [[5lck]], [[5ngu]], [[5nhf]], [[5nhh]], [[5nhj]], [[5nhl]], [[5nho]], [[5nhp]], [[5nhv]], [[5u6i]] – hMAPK1+inhibitor - human<br /> |
**[[2y9q]] – hMAPK1 + MAP kinase-interacting Ser/Thr protein kinase peptide<br /> | **[[2y9q]] – hMAPK1 + MAP kinase-interacting Ser/Thr protein kinase peptide<br /> | ||
| - | **[[3tei]] – hMAPK1 (mutant) + ribosomal protein S6 kinase α-1<br /> | + | **[[3tei]], [[4h3p]], [[4nif]] – hMAPK1 (mutant) + ribosomal protein S6 kinase α-1<br /> |
**[[4iz5]], [[4iz7]], [[4iza]] – hMAPK1 (mutant) + astrocytic phosphoprotein <br /> | **[[4iz5]], [[4iz7]], [[4iza]] – hMAPK1 (mutant) + astrocytic phosphoprotein <br /> | ||
**[[4fmq]] – hMAPK1 + MAPK docking peptide<br /> | **[[4fmq]] – hMAPK1 + MAPK docking peptide<br /> | ||
**[[4h3q]] – hMAPK1 + MAP2K 2 peptide<br /> | **[[4h3q]] – hMAPK1 + MAP2K 2 peptide<br /> | ||
| - | **[[2z7l]], [[3c9w]], [[3qyw]], [[3qyz]] - rMAPK1+inhibitor – rat<br /> | + | **[[5ax3]] – hMAPK1 + allosteric inhibitor peptide<br /> |
| - | **[[1erk]] - rMAPK1<br /> | + | **[[4n0s]] – hMAPK1 + cafeic acid<br /> |
| - | **[[1gol]], [[3r63]] - rMAPK1 (mutant)<br /> | + | **[[4zxt]] – hMAPK1 + catechol<br /> |
| + | **[[2z7l]], [[3c9w]], [[3qyw]], [[3qyz]], [[4qyy]] - rMAPK1+inhibitor – rat<br /> | ||
| + | **[[1erk]], [[4s31]], [[5umo]] - rMAPK1<br /> | ||
| + | **[[1gol]], [[3r63]], [[4s2z]], [[4s30]] - rMAPK1 (mutant)<br /> | ||
**[[2gph]] - rMAPK1 (mutant)+HEPTP (mutant)<br /> | **[[2gph]] - rMAPK1 (mutant)+HEPTP (mutant)<br /> | ||
**[[3o71]] - rMAPK1 + colorectal cancer peptide<br /> | **[[3o71]] - rMAPK1 + colorectal cancer peptide<br /> | ||
**[[2fys]] - rMAPK1 + KIM peptide<br /> | **[[2fys]] - rMAPK1 + KIM peptide<br /> | ||
| + | **[[4s32]] – rMAPK1 + AMPPNP<br /> | ||
| + | **[[4s33]], [[4s34]] – rMAPK1 (mutant) + AMPPNP<br /> | ||
**[[4gt3]], [[4gva]] – rMAPK1 + nucleotide<br /> | **[[4gt3]], [[4gva]] – rMAPK1 + nucleotide<br /> | ||
**[[4i5h]] – rMAPK1 (mutant) + inhibitor<br /> | **[[4i5h]] – rMAPK1 (mutant) + inhibitor<br /> | ||
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*MAPK2 | *MAPK2 | ||
| + | **[[1kwp]] – hMAPK2<br /> | ||
**[[3gok]] - hMAPK2 kinase domain<br /> | **[[3gok]] - hMAPK2 kinase domain<br /> | ||
| - | **[[2pzy]], [[2p3g]], [[2jbo]], [[2jbp]] – hMAPK2+inhibitor<br /> | + | **[[2pzy]], [[2p3g]], [[2jbo]], [[2jbp]] – hMAPK2 kinase domain +inhibitor<br /> |
| - | **[[3a2c]], [[3kc3]], [[3fpm]], [[3fyj]], [[3fyk]] - hMAPK2 kinase domain +inhibitor<br /> | + | **[[3a2c]], [[3kc3]], [[3fpm]], [[3fyj]], [[3fyk]], [[3r2b]], [[3r2y]], [[3r30]], [[3wi6]] - hMAPK2 kinase domain +inhibitor<br /> |
| - | **[[3m2w]], [[3kga]], [[3ka0]] – hMAPK2 kinase domain (mutant)+inhibitor<br /> | + | **[[3m2w]], [[3kga]], [[3ka0]], [[3m42]] – hMAPK2 kinase domain (mutant)+inhibitor<br /> |
| - | **[[2oza]], [[ | + | **[[2oza]], [[2onl]] – hMAPK2+ hMAPK14<br /> |
| - | **[[2npt]] - hMAPK2+ hMAPK5<br /> | + | **[[4tyh]] - hMAPK2+ hMAPK14 + inhibitor<br /> |
| + | **[[1nxk]] – hMAPK2 + staurosporine<br /> | ||
| + | **[[1ny3]] – hMAPK2 + ADP<br /> | ||
| + | **[[2npt]] - hMAPK2 PHOX domain + hMAPK5<br /> | ||
**[[2erk]] – rMAPK2<br /> | **[[2erk]] – rMAPK2<br /> | ||
**[[3erk]], [[4erk]] – rMAPK2+inhibitor<br /> | **[[3erk]], [[4erk]] – rMAPK2+inhibitor<br /> | ||
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**[[2zoq]] – hMAPK3<br /> | **[[2zoq]] – hMAPK3<br /> | ||
| + | **[[3r1n]], [[3she]], [[4qtb]] – hMAPK3 kinase domain +inhibitor<br /> | ||
*MAPK6 | *MAPK6 | ||
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**[[4ic8]] – hMAPK7<br /> | **[[4ic8]] – hMAPK7<br /> | ||
| - | **[[4b99]] – hMAPK7+inhibitor<br /> | + | **[[4b99]], [[4zsg]], [[4zsj]], [[4zsl]], [[5byy]], [[5byz]] – hMAPK7+inhibitor<br /> |
**[[4ic7]] – hMAPK7+ MAP2K 5<br /> | **[[4ic7]] – hMAPK7+ MAP2K 5<br /> | ||
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**[[3o2m]] - hMAPK8 (mutant)+JIP1 peptide+biaryl tetrazole<br /> | **[[3o2m]] - hMAPK8 (mutant)+JIP1 peptide+biaryl tetrazole<br /> | ||
**[[2xrw]], [[2xs0]] - hMAPK8 + NFAT peptide<br /> | **[[2xrw]], [[2xs0]] - hMAPK8 + NFAT peptide<br /> | ||
| - | **[[3elj]], [[3pze]], [[4awi]], [[4l7f]] - hMAPK8+inhibitor<br /> | + | **[[4ux9]] – hMAPK8 + MAPKK7 peptide<br /> |
| + | **[[4yr8]] – hMAPK8 + MKP7 <br /> | ||
| + | **[[3elj]], [[3pze]], [[4awi]], [[4l7f]], [[4qtd]] - hMAPK8+inhibitor<br /> | ||
**[[4e73]], [[4g1w]], [[4hys]], [[4hyu]], [[4izy]] – hMAPK8 + JIP1 +inhibitor<br /> | **[[4e73]], [[4g1w]], [[4hys]], [[4hyu]], [[4izy]] – hMAPK8 + JIP1 +inhibitor<br /> | ||
**[[2no3]], [[2h96]] – hMAPK8 (mutant)+inhibitor<br /> | **[[2no3]], [[2h96]] – hMAPK8 (mutant)+inhibitor<br /> | ||
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*MAPK10 | *MAPK10 | ||
| - | **[[3kvx]], [[3fv8]], [[2waj]], [[3fi2]], [[3fi3]], [[3da6]], [[2zdt]], [[2zdu]], [[3cgf]], [[3cgo]], [[2r9s]], [[2o0u]], [[2o2u]], [[2exc]], [[2b1p]], [[1pmn]], [[4z9l]], [[1pmu]], [[1pmv]], [[3oy1]], [[2ok1]], [[3ttj]], [[3tti]], [[3rtp]], [[3v6r]], [[3v6s]] – hMAPK10+inhibitor<br /> | + | **[[3kvx]], [[3fv8]], [[2waj]], [[3fi2]], [[3fi3]], [[3da6]], [[2zdt]], [[2zdu]], [[3cgf]], [[3cgo]], [[2r9s]], [[2o0u]], [[2o2u]], [[2exc]], [[2b1p]], [[1pmn]], [[4z9l]], [[1pmu]], [[1pmv]], [[3oy1]], [[2ok1]], [[3ttj]], [[3tti]], [[3rtp]], [[3v6r]], [[3v6s]], [[4kkh]], [[4u79]], [[4whz]], [[4x21]], [[4y46]], [[4y5h]] – hMAPK10+inhibitor<br /> |
**[[3ptg]], [[4h39]] - hMAPK10 catalytic domain + JIP1 peptide <br /> | **[[3ptg]], [[4h39]] - hMAPK10 catalytic domain + JIP1 peptide <br /> | ||
**[[4h36]] – hMAPK10 catalytic domain + ATF2 peptide<br /> | **[[4h36]] – hMAPK10 catalytic domain + ATF2 peptide<br /> | ||
**[[4h3b]] – hMAPK10 catalytic domain + SAB peptide<br /> | **[[4h3b]] – hMAPK10 catalytic domain + SAB peptide<br /> | ||
| - | **[[ | + | **[[4kke]], [[4kkg]] – hMAPK10 catalytic domain + AMPPNP<br /> |
**[[3g9l]], [[3g90]], [[3g9n]], [[2p33]] – hMAPK10 catalytic domain+inhibitor<br /> | **[[3g9l]], [[3g90]], [[3g9n]], [[2p33]] – hMAPK10 catalytic domain+inhibitor<br /> | ||
**[[3oxi]] - hMAPK10 + MAPK8 interacting protein + inhibitor<br /> | **[[3oxi]] - hMAPK10 + MAPK8 interacting protein + inhibitor<br /> | ||
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*MAPK13 | *MAPK13 | ||
| - | **[[3coi]], [[4yno]] – hMAPK13<br /> | + | **[[3coi]], [[4yno]], [[4myg]] – hMAPK13<br /> |
| - | **[[4eyj]], [[4eym]] - hMAPK13 +inhibitor<br /> | + | **[[4eyj]], [[4eym]], [[5ekn]], [[5eko]] - hMAPK13 +inhibitor<br /> |
*MAPK14 | *MAPK14 | ||
| - | **[[3mgy]], [[3mh0]], [[3mh1]], [[3mh2]], [[3mh3]], [[3hvc]], [[3npq]], [[1wbo]], [[1r39]], [[2npq]], [[1wfc]], [[1cm8]] – hMAPK14<br /> | + | **[[3mgy]], [[3mh0]], [[3mh1]], [[3mh2]], [[3mh3]], [[3hvc]], [[3npq]], [[1wbo]], [[1r39]], [[2npq]], [[1wfc]], [[1cm8]], [[5etc]], [[5eti]], [[5uoj]] – hMAPK14<br /> |
**[[2lgc]] – hMAPK14 – NMR<br /> | **[[2lgc]] – hMAPK14 – NMR<br /> | ||
**[[3od6]], [[3ody]], [[3odz]], [[3oef]], [[3p4k]], [[2fsl]], [[2fsm]], [[2fso]], [[2fst]], [[1r3c]], [[4e5a]], [[4geo]] – hMAPK14 (mutant)<br /> | **[[3od6]], [[3ody]], [[3odz]], [[3oef]], [[3p4k]], [[2fsl]], [[2fsm]], [[2fso]], [[2fst]], [[1r3c]], [[4e5a]], [[4geo]] – hMAPK14 (mutant)<br /> | ||
| - | **[[3new]], [[3ocg]], [[3mvl]], [[3mvm]], [[3nnu]], [[3nnv]], [[3nnw]], [[3nnx]], [[3nww]], [[3mpt]], [[3lhj]], [[3huc]], [[3itz]], [[3l8x]], [[3kf7]], [[3fi4]], [[3fkl]], [[3fkn]], [[3fko]], [[3fl4]], [[3fln]], [[3flq]], [[3fls]], [[3flw]], [[3fly]], [[3flz]], [[3fmh]], [[3fmj]], [[3fmk]], [[3fml]], [[3flm]], [[3fln]], [[3fsf]], [[3fsk]], [[3kq7]], [[3iph]], [[3hv4]], [[3hv5]], [[3hv6]], [[3hv7]], [[3k3i]], [[3hec]], [[3heg]], [[3gi3]], [[3hp2]], [[3hp5]], [[3hrb]], [[3ha8]], [[3gfe]], [[3hl7]], [[3hll]], [[3gcu]], [[3fc1]], [[3dt1]], [[3e92]], [[3e93]], [[3d7z]], [[3d83]], [[3ctq]], [[2puu]], [[3bx5]], [[3c5u]], [[2zaz]], [[2zb0]], [[2zb1]], [[2qd9]], [[2ewa]], [[2gfs]], [[2baj]], [[2bak]], [[2bal]], [[2baq]], [[1zyj]], [[1wbn]], [[1wbs]], [[1wbt]], [[1wbv]], [[1wbw]], [[1zz2]], [[1zzl]], [[1yqj]], [[1w7h]], [[1w82]], [[1w83]], [[1w84]], [[1oz1]], [[1ouk]], [[1ouy]], [[1m7q]], [[1kv1]], [[1kv2]], [[1di9]], [[2rg5]], [[2rg6]], [[3bv3]], [[3bv2]], [[3fmm]], [[3fmn]], [[3lfa]], [[3mw1]], [[3pg3]], [[3roc]] ,[[2yis]], [[2yiw]], [[2yix]], [[3qud]], [[3que]], [[3rin]], [[3s3i]], [[3s4q]], [[3u8w]], [[3uvp]], [[3uvq]], [[3uvr]], [[3zs5]], [[3zsg]], [[3zsh]], [[3zsi]], [[3zya]], [[4a9y]], [[4aa0]], [[4aa4]], [[4aa5]], [[4aac]], [[4dli]], [[4dlj]], [[4e5b]], [[4eh2]], [[4eh3]], [[4eh4]], [[4eh5]], [[4eh6]], [[4eh7]], [[4eh8]], [[4eh9]], [[4ehv]], [[4ewq]], [[4f9w]], [[4f9y]], [[4fa2]], [[4kin]], [[4kip]], [[4kiq]], [[4l8m]] - hMAPK14+inhibitor<br /> | + | **[[3new]], [[3ocg]], [[3mvl]], [[3mvm]], [[3nnu]], [[3nnv]], [[3nnw]], [[3nnx]], [[3nww]], [[3mpt]], [[3lhj]], [[3huc]], [[3itz]], [[3l8x]], [[3kf7]], [[3fi4]], [[3fkl]], [[3fkn]], [[3fko]], [[3fl4]], [[3fln]], [[3flq]], [[3fls]], [[3flw]], [[3fly]], [[3flz]], [[3fmh]], [[3fmj]], [[3fmk]], [[3fml]], [[3flm]], [[3fln]], [[3fsf]], [[3fsk]], [[3kq7]], [[3iph]], [[3hv4]], [[3hv5]], [[3hv6]], [[3hv7]], [[3k3i]], [[3hec]], [[3heg]], [[3gi3]], [[3hp2]], [[3hp5]], [[3hrb]], [[3ha8]], [[3gfe]], [[3hl7]], [[3hll]], [[3gcu]], [[3fc1]], [[3dt1]], [[3e92]], [[3e93]], [[3d7z]], [[3d83]], [[3ctq]], [[2puu]], [[3bx5]], [[3c5u]], [[2zaz]], [[2zb0]], [[2zb1]], [[2qd9]], [[2ewa]], [[2gfs]], [[2baj]], [[2bak]], [[2bal]], [[2baq]], [[1zyj]], [[1wbn]], [[1wbs]], [[1wbt]], [[1wbv]], [[1wbw]], [[1zz2]], [[1zzl]], [[1yqj]], [[1w7h]], [[1w82]], [[1w83]], [[1w84]], [[1oz1]], [[1ouk]], [[1ouy]], [[1m7q]], [[1kv1]], [[1kv2]], [[1di9]], [[2rg5]], [[2rg6]], [[3bv3]], [[3bv2]], [[3fmm]], [[3fmn]], [[3lfa]], [[3mw1]], [[3pg3]], [[3roc]] ,[[2yis]], [[2yiw]], [[2yix]], [[3qud]], [[3que]], [[3rin]], [[3s3i]], [[3s4q]], [[3u8w]], [[3uvp]], [[3uvq]], [[3uvr]], [[3zs5]], [[3zsg]], [[3zsh]], [[3zsi]], [[3zya]], [[4a9y]], [[4aa0]], [[4aa4]], [[4aa5]], [[4aac]], [[4dli]], [[4dlj]], [[4e5b]], [[4eh2]], [[4eh3]], [[4eh4]], [[4eh5]], [[4eh6]], [[4eh7]], [[4eh8]], [[4eh9]], [[4ehv]], [[4ewq]], [[4f9w]], [[4f9y]], [[4fa2]], [[4kin]], [[4kip]], [[4kiq]], [[4l8m]], [[4r3c]], [[4zth]], [[5lar]], [[5ml5]], [[5tbe]], [[5tco]] - hMAPK14+inhibitor<br /> |
**[[4e6a]], [[4e6c]], [[4e8a]] - hMAPK14+ lipid<br /> | **[[4e6a]], [[4e6c]], [[4e8a]] - hMAPK14+ lipid<br /> | ||
**[[3o8t]], [[3mpa]], [[3obg]], [[3o8u]], [[3o8p]], [[3obj]], [[3oc1]], [[3hub]], [[3l8s]], [[3hv3]], [[3iw5]], [[3iw6]], [[3iw7]], [[3iw8]], [[3k3j]], [[3gc7]], [[3gcp]], [[3gcq]], [[3gcs]], [[3gcv]], [[3ds6]], [[2i0h]], [[1ove]], [[3lfb]], [[3lfc]], [[3lfd]], [[3lfe]], [[3lff]], [[1bl6]], [[1bl7]], [[1bmk]], [[1a9u]], [[1ian]] - hMAPK14 (mutant)+inhibitor<br /> | **[[3o8t]], [[3mpa]], [[3obg]], [[3o8u]], [[3o8p]], [[3obj]], [[3oc1]], [[3hub]], [[3l8s]], [[3hv3]], [[3iw5]], [[3iw6]], [[3iw7]], [[3iw8]], [[3k3j]], [[3gc7]], [[3gcp]], [[3gcq]], [[3gcs]], [[3gcv]], [[3ds6]], [[2i0h]], [[1ove]], [[3lfb]], [[3lfc]], [[3lfd]], [[3lfe]], [[3lff]], [[1bl6]], [[1bl7]], [[1bmk]], [[1a9u]], [[1ian]] - hMAPK14 (mutant)+inhibitor<br /> | ||
**[[2y8o]] – hMAPK14 (mutant) + dual specificity MAP2K peptide<br /> | **[[2y8o]] – hMAPK14 (mutant) + dual specificity MAP2K peptide<br /> | ||
**[[4ka3]], [[4loo]], [[4lop]], [[4loq]] – hMAPK14 + docking peptide<br /> | **[[4ka3]], [[4loo]], [[4lop]], [[4loq]] – hMAPK14 + docking peptide<br /> | ||
| + | **[[5eta]] – hMAPK14 + peptide<br /> | ||
**[[3tg1]] – hMAPK14 + MAPK phosphatase 5<br /> | **[[3tg1]] – hMAPK14 + MAPK phosphatase 5<br /> | ||
| + | **[[5etf]] – hMAPK14 + MAPKK 6<br /> | ||
**[[2gtn]], [[2gtm]], [[3p5k]], [[3p78]], [[3p79]], [[3p7a]], [[3p7b]], [[3p7c]] - mMAPK14+inhibitor<br /> | **[[2gtn]], [[2gtm]], [[3p5k]], [[3p78]], [[3p79]], [[3p7a]], [[3p7b]], [[3p7c]] - mMAPK14+inhibitor<br /> | ||
**[[2ghm]], [[2ghl]], [[1ywr]] - mMAPK14 (mutant)+inhibitor<br /> | **[[2ghm]], [[2ghl]], [[1ywr]] - mMAPK14 (mutant)+inhibitor<br /> | ||
Revision as of 09:12, 23 July 2017
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3D Structures of Mitogen-activated protein kinase
Updated on 23-July-2017
References
- ↑ Robinson MJ, Cobb MH. Mitogen-activated protein kinase pathways. Curr Opin Cell Biol. 1997 Apr;9(2):180-6. PMID:9069255
- ↑ Aronov AM, Baker C, Bemis GW, Cao J, Chen G, Ford PJ, Germann UA, Green J, Hale MR, Jacobs M, Janetka JW, Maltais F, Martinez-Botella G, Namchuk MN, Straub J, Tang Q, Xie X. Flipped out: structure-guided design of selective pyrazolylpyrrole ERK inhibitors. J Med Chem. 2007 Mar 22;50(6):1280-7. Epub 2007 Feb 15. PMID:17300186 doi:http://dx.doi.org/10.1021/jm061381f
