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Monooxygenase

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*'''Toluene 4-monooxygenase (TMO)'''
*'''Toluene 4-monooxygenase (TMO)'''
-
**[[3dhg]], [[3i5j]] – PmTMO α+β+γ subunits + Fe – ''Pseudomonas mendocina''<br />
+
**[[3dhg]], [[3i5j]], [[2inc]] – PmTMO α+β+γ subunits + Fe – ''Pseudomonas mendocina''<br />
 +
**[[2ind]] – PmTMO α+β+γ subunits + Mn <br />
 +
**[[3rng]], [[3rnf]], [[3rne]], [[3rnc]], [[3rnb]], [[3rna]], [[3rn9]], [[3n20]], [[3n1z]], [[3n1y]], [[3n1x]], [[2rdb]] – PmTMO α+β+γ subunits (mutant) + Fe <br />
**[[1sjg]] – PmTMO protein C + Fe <br />
**[[1sjg]] – PmTMO protein C + Fe <br />
**[[1vm9]] – PmTMO protein C (mutant) + Fe <br />
**[[1vm9]] – PmTMO protein C (mutant) + Fe <br />
 +
**[[2bf5]], [[2bf3]], [[2bf2]] – PmTMO protein D <br />
 +
**[[4wqm]] – PmTMO (mutant) + Ni <br />
 +
**[[4p1c]], [[4p1b]] – PmTMO protein A+B+E+ferredoxin (mutant) + Fe <br />
 +
**[[2q3w]] – PmTMO ferredoxin subunit (mutant) + Fe <br />
*TMO complexes
*TMO complexes
**[[3dhh]], [[3q3n]], [[3q3o]] – PmTMO α+β+γ subunits + Fe + phenol derivative + TMO system effector protein<br />
**[[3dhh]], [[3q3n]], [[3q3o]] – PmTMO α+β+γ subunits + Fe + phenol derivative + TMO system effector protein<br />
-
**[[3rmk]] – PmTMO α+β+γ subunits + Fe + phenol derivative<br />
+
**[[3rmk]], [[1t0s]], [[1t0q]] – PmTMO α+β+γ subunits + Fe + phenol derivative<br />
**[[3q14]] – PmTMO α+β+γ subunits + Fe + p-cresol + TMO system effector protein<br />
**[[3q14]] – PmTMO α+β+γ subunits + Fe + p-cresol + TMO system effector protein<br />
**[[3q2a]], [[3q3m]] – PmTMO α+β+γ subunits + Fe + benzoate inhibitor + TMO system effector protein<br />
**[[3q2a]], [[3q3m]] – PmTMO α+β+γ subunits + Fe + benzoate inhibitor + TMO system effector protein<br />
Line 31: Line 37:
**[[3ge3]], [[3ge8]], [[3ri7]] – PmTMO α (mutant)+β+γ subunits + Fe + TMO system effector protein<br />
**[[3ge3]], [[3ge8]], [[3ri7]] – PmTMO α (mutant)+β+γ subunits + Fe + TMO system effector protein<br />
**[[3i63]] – PmTMO α+β+γ subunits + Fe + TMO system effector protein + H2O2<br />
**[[3i63]] – PmTMO α+β+γ subunits + Fe + TMO system effector protein + H2O2<br />
 +
**[[5tdv]] – PmTMO protein A+B+D+E + Fe + peroxide<br />
 +
**[[5tdu]] – PmTMO protein A+B+D+E + Fe + cresol<br />
 +
**[[5tdt]] – PmTMO protein A+B+D+E + Fe + peroxide + toluene<br />
 +
**[[5tds]] – PmTMO protein A+B+D+E + Fe + toluene<br />
 +
**[[1t0r]] – PsTMO + Fe + OH – ''Pseudomonas stutzeri''<br />
*'''Heme-degrading monooxygenase (IsdI)'''
*'''Heme-degrading monooxygenase (IsdI)'''
**[[2zdp]] – SaIsdI + heme-Co – ''Staphylococcus aureus''<br />
**[[2zdp]] – SaIsdI + heme-Co – ''Staphylococcus aureus''<br />
-
**[[3lgm]] – SaIsdI + heme-Fe<br />
+
**[[3lgm]], [[2zdo]] – SaIsdI + heme-Fe<br />
**[[4fnh]] – SaIsdI (mutant) + heme-Fe<br />
**[[4fnh]] – SaIsdI (mutant) + heme-Fe<br />
**[[3lgn]] – SaIsdI + heme-Fe + O2<br />
**[[3lgn]] – SaIsdI + heme-Fe + O2<br />
**[[3qgp]] – SaIsdI + heme-Fe + CN<br />
**[[3qgp]] – SaIsdI + heme-Fe + CN<br />
**[[4fni]] – SaIsdI (mutant) + heme-Fe + CN<br />
**[[4fni]] – SaIsdI (mutant) + heme-Fe + CN<br />
 +
**[[4nl5]] – MtMO + heme + CN – ''Mycobacterium tuberculosis''<br />
 +
**[[4oz5]] – MO + heme – ''Bacillus subtilis''<br />
*'''Kynurenine 3-monooxygenase (KMO)'''
*'''Kynurenine 3-monooxygenase (KMO)'''
Line 45: Line 58:
**[[4j2w]], [[4j31]], [[4j33]], [[4j34]] – yKMO + FAD – yeast<br />
**[[4j2w]], [[4j31]], [[4j33]], [[4j34]] – yKMO + FAD – yeast<br />
**[[4j36]] – yKMO + FAD + inhibitor<br />
**[[4j36]] – yKMO + FAD + inhibitor<br />
 +
**[[5na5]] – PfKMO (mutant) + FAD – ''Pseudomonas fluorescens''<br />
 +
**[[5nak]] – PfKMO (mutant) + FAD + kynurenine <br />
 +
**[[5nah]], [[5nag]], [[5nae]], [[5nab]], [[5n7t]], [[5mzk]], [[5mzi]], [[5mzc]], [[5fn0]] – PfKMO (mutant) + FAD + inhibitor<br />
*'''Phenol 2-monooxygenase (PMO)'''
*'''Phenol 2-monooxygenase (PMO)'''
Line 66: Line 82:
**[[2gv8]] – fyMO + FAD + NADP – fission yeast<br />
**[[2gv8]] – fyMO + FAD + NADP – fission yeast<br />
**[[2gvc]] – fyMO + FAD + NADP + methimazole<br />
**[[2gvc]] – fyMO + FAD + NADP + methimazole<br />
-
**[[4a9w]] – MO + FAD – ''Stenotrophomonas maltophilia''<br />
+
**[[4a9w]] – SmMO + FAD – ''Stenotrophomonas maltophilia''<br />
 +
**[[4c5o]] – SmMO (mutant) + FAD <br />
 +
**[[5wan]] – MO + FMN + uracil – Escherichia coli<br />
 +
**[[5iq4]], [[5iq1]], [[5ipy]] – RnMO (mutant) + FAD + NAP – ''Roseovarius nubinhibens'' <br />
 +
**[[5gsn]] – RnMO (mutant) + FAD + NAP + methimazole <br />
 +
**[[4usr]] – PsMO + FAD <br />
 +
**[[3rp6]] – KpMO + FAD – ''Klebsiella pneumoniae''<br />
 +
**[[3rp8]] – KpMO (mutant) + FAD <br />
 +
**[[3rp7]] – KpMO + FAD + uric acid<br />
 +
**[[3c96]], [[2rgj]] – PaMO + FAD – ''Pseudomonas aeruginosa''<br />
 +
**[[2xvf]], [[2xve]] – MaMO + FAD – ''Methylophaga aminisulfidivorans'' <br />
 +
**[[2xvj]] – MaMO (mutant) + FAD + indole <br />
 +
**[[2xvi]] – MaMO (mutant) + FAD + O2<br />
 +
**[[2vqb]] – MaMO (mutant) + FAD + NADP + O2<br />
 +
**[[2xvh]], [[2xlu]], [[2xlt]] – MaMO + FAD + NADP derivative<br />
 +
**[[2xls]], [[2xlr]], [[2xlp]], [[2vq7]] – MaMO (mutant) + FAD + NADP <br />
-
**[[2i7g]] – MO – ''Agrobacterium tumefaciens''<br />
+
*Pentachlorophenol 4-monooxygenase
 +
**[[5kox]] – NfMO + FAD – ''Nocardia farcinica''<br />
 +
**[[5kox]] – NfMO + FAD + rifampicin <br />
 +
*2,4,6-trichlorophenol 4-monooxygenase
 +
 +
**[[4g5e]] – MO – ''Cupriavidus necator''<br />
 +
 +
*Chlorophenol 4-monooxygenase
 +
 +
**[[4oo2]] – MO – ''Streptomyces globisporus''<br />
 +
**[[3k86]], [[3hwc]] – BcMO – ''Burkholderia cepacia'' <br />
 +
**[[3k87]] – BcMO + FAD <br />
 +
**[[3k88]] – BcMO + FAD + NAD <br />
 +
 +
*Phenylacetone monooxygenase
 +
 +
**[[4ovi]], [[4c74]] – TfMO + FAD + APADP – ''Thermobifida fusca''<br />
 +
**[[1w4x]] – TfMO + FAD<br />
 +
**[[2ylt]], [[2yls]], [[2ylr]] – TfMO + FAD + NADP <br />
 +
**[[2ylz]] – TfMO (mutant) + FAD <br />
 +
**[[4c77]] – TfMO (mutant) + FAD + APADP <br />
 +
**[[4d04]] – TfMO (mutant) + FAD + NAP <br />
 +
**[[4d03]], [[2ym2]], [[2ylx]], [[2ylw]] – TfMO (mutant) + FAD + NADP <br />
 +
**[[2ym1]] – TfMO (mutant) + FAD + NADP + O2<br />
 +
 +
*6-hydroxynicotinate 3-monooxygenase
 +
 +
**[[5eow]] – PpMO + FAD – ''Pseudomonas putida''<br />
 +
 +
*Styrene monooxygenase
 +
 +
**[[3ihm]] – PpMO <br />
 +
**[[4f07]] – PpMO (mutant) + FAD <br />
 +
 +
*Tryptophan 2-monooxygenase
 +
 +
**[[4iv9]] – MO + FAD – ''Pseudomonas savastanoi''<br />
 +
 +
*Tryptophan 5-monooxygenase
 +
 +
**[[1mlw]] – hMO + Fe + dihydrobiopterin <br />
 +
 +
*Tyrosine 3-monooxygenase
 +
 +
**[[2xsn]] – hMO + Zn<br />
 +
**[[2toh]] – rMO + Fe + dihydrobiopterin + tyrosine - rat<br />
 +
**[[2mda]] – rMO regulatory domain <br />
 +
 +
*Nitronate monooxygenase
 +
 +
**[[4q4k]] – PaMO + FMN <br />
 +
**[[5lsm]] – MO + FMN – ''Shewanella oneidensis''<br />
 +
 +
*2-hydroxbiphenyl 3-monooxygenase
 +
 +
**[[4z2r]] – PnMO + FAD – ''Pseudomonas nitroreducens''<br />
 +
**[[4cy6]] – PnMO (mutant) <br />
 +
**[[4z2u]], [[4z2t]], [[4cy8]] – PnMO (mutant) + FAD <br />
 +
**[[5brt]] – PnMO + FAD + hydroxybephenyl <br />
 +
 +
*4-hydroxyphenylacetate 3-monooxygenase
 +
 +
**[[4ira]] – BmMO + FAD – Brucella melitensis<br />
 +
**[[3cb0]] – BmMO + FMN<br />
 +
 +
*Ornithine N(5)-monooxygenase
 +
 +
**[[5cku]] – MO + FAD + NADP + ornithine – ''Neosartorya fumigata''<br />
 +
**[[4nzh]], [[4b69]] – AfMO + FAD + ornithine – ''Aspergillus fumigatus''<br />
 +
**[[4b65]] – AfMO + FAD + NADP <br />
 +
**[[4b68]], [[4b66]] – AfMO + FAD + NAP + arginine <br />
 +
**[[4b67]], [[4b63]] – AfMO + FAD + NADP + ornithine <br />
 +
**[[4b64]] – AfMO + FAD + NADP + lysine <br />
 +
**[[3s61]], [[5s5w]] – PaMO + FAD + NADP + ornithine derivative<br />
 +
 +
*Steroid monooxygenase
 +
 +
**[[4ap1]], [[4aos]] – RrMO + FAD + NADP – ''Rhodococcus rhodochrous''<br />
 +
**[[4aox]] – RrMO (mutant) + FAD <br />
 +
**[[4ap3]] – RrMO (mutant) + FAD + NADP <br />
 +
 +
*Cyclohexanone monooxygenase
 +
 +
**[[5m10]] – TmMO + FAD + NAP + nicotinamide – ''Thermocripsum municipale''''Italic text''<br />
 +
**[[5m0z]] – TmMO + FAD + NADP derivative <br />
 +
**[[4rg4]], [[4rg3]], [[3gwf]], [[3gwd]] – RhMO + FAD + NAP + caprolactone – ''Rhodococcus''<br />
 +
**[[3ucl]] – RhMO + FAD + NADP + cyclohexanone <br />
 +
 +
*Lysine 6-monooxygenase
 +
 +
**[[5cqf]] – MO – ''Pseudomonas syringae''<br />
 +
**[[4d7e]] – MO (mutant) + FAD – ''Nocardia farcinica''<br />
 +
 +
*EDTA monooxygenase
 +
 +
**[[5dqp]] – MO – ''Chelativorans''<br />
 +
 +
*3,6-diketocamphane 1,6 monooxygenase
 +
 +
**[[5aec]] – PpMO <br />
 +
**[[4uwm]] – PpMO + FMN<br />
 +
 +
*Lytic polysaccharide monooxygenase
 +
 +
**[[5tki]], [[5foh]], [[4qi8]] – NcMO-2 + Cu – ''Neurospora crassa''''Italic text''<br />
 +
**[[5tkh]], [[5tkg]], [[5tkf]], [[4eir]] – NcMO-2 + Cu + O2 <br />
 +
**[[4eis]] – NcMO-3 + Cu + peroxide <br />
 +
**[[5iju]] – MO + Cu – ''Bacillus amyloliquefaciens''<br />
 +
**[[5acj]], [[5aci]], [[5ach]], [[5acg]], [[5acf]] – MO + Cu – ''Lentinus similis''<br />
 +
**[[4mai]] – moMO + Cu – mold<br />
 +
**[[4mah]] – moMO + Zn<br />
 +
 +
*Peptidyl-glycine alpha-amidating monooxygenase
 +
 +
**[[3mib]], [[3mic]], [[3mid]], [[3mie]], [[3mif]], [[3mig]], [[3mih]], [[3mlj]], [[3mlk]], [[3mll]], [[1opm]] – rMO + Cu + Ni <br />
 +
**[[1sdw]] – rMO + Cu + Ni + O2 + threonine derivative<br />
 +
**[[1yjl]] – rMO (mutant)<br />
 +
**[[1yjk]], [[1yip]], [[1phm]] – rMO + Cu<br />
 +
**[[1yi9]] – rMO (mutant) + Cu<br />
 +
**[[3fw0]] – rMO + Hg<br />
 +
**[[3fvz]] – rMO + Zn + Fe<br />
 +
 +
*Antibiotic biosynthesis monooxygenase
 +
 +
**[[4hl9]] – MO – ''Rhodospirillum rubrum''<br />
 +
**[[4dn9]] – MO – ''Chloroflexus aurantiacus''<br />
 +
**[[2ril]] – MO – ''Shewanella loihica''<br />
 +
 +
*Monooxygenase
 +
 +
**[[2i7g]] – MO – ''Agrobacterium tumefaciens''<br />
 +
**[[5uq4]] – MtMO <br />
 +
**[[5f5l]] – MiMO – ''Micromonospora'' <br />
 +
**[[5f5n]] – MiMO + NAD + substrate <br />
'''Methane monooxygenase''' See [[Methane monooxygenase]]
'''Methane monooxygenase''' See [[Methane monooxygenase]]

Revision as of 10:07, 25 July 2017

Polysaccharide monooxygenase complex with Cu(II) and PEG (PDB code 4alq)

Drag the structure with the mouse to rotate

3D structures of monooxygenase

Updated on 25-July-2017

Methane monooxygenase See Methane monooxygenase

Camphor 5-monooxygenase See Cytochrome P450

Luciferin 4-monooxygenase and Alkanal monooxygenase See Luciferase

References

  1. ↑ Rudzka K, Moreno DM, Eipper B, Mains R, Estrin DA, Amzel LM. Coordination of peroxide to the Cu(M) center of peptidylglycine alpha-hydroxylating monooxygenase (PHM): structural and computational study. J Biol Inorg Chem. 2012 Dec 18. PMID:23247335 doi:10.1007/s00775-012-0967-z

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman, Alexander Berchansky, Jaime Prilusky

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