Mur ligase
From Proteopedia
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m (MurD ligase moved to Mur ligase over redirect: requested by Editor) |
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*'''MurD''' | *'''MurD''' | ||
| - | **[[1e0d]] – EcMurD – ''Escherichia coli'' <br /> | + | **[[1e0d]], [[5a5e]] – EcMurD – ''Escherichia coli'' <br /> |
**[[3lk7]] – MurD – ''Streptococcus agalactiae''<br /> | **[[3lk7]] – MurD – ''Streptococcus agalactiae''<br /> | ||
**[[4buc]] – TmMurD – ''Thermotoga maritima''<br /> | **[[4buc]] – TmMurD – ''Thermotoga maritima''<br /> | ||
| Line 33: | Line 33: | ||
**[[2uag]] – EcMurD + UMA + ADP + Mg<br /> | **[[2uag]] – EcMurD + UMA + ADP + Mg<br /> | ||
**[[3uag]] – EcMurD + UMA + ADP + Mn<br /> | **[[3uag]] – EcMurD + UMA + ADP + Mn<br /> | ||
| + | **[[5a5f]] – EcMurD + UMA + ADP + malonate<br /> | ||
**[[4uag]] – EcMurD + UAG<br /> | **[[4uag]] – EcMurD + UAG<br /> | ||
**[[4bub]] – TmMurD + ADP <br /> | **[[4bub]] – TmMurD + ADP <br /> | ||
| Line 48: | Line 49: | ||
*MurE | *MurE | ||
| - | **[[2xja]] – | + | **[[2xja]] – MtMurE + dipeptide + ADP – ''Mycobacterium tuberculosis'' <br /> |
| + | **[[2wtz]] – MtMurE + UAG <br /> | ||
| + | **[[1e8c]] – EcMurE + UDP-tripeptide + UAG <br /> | ||
| + | **[[4c12]] – SaMurE + UML + ADP – ''Staphylococcus aureus'' <br /> | ||
| + | **[[4c13]] – SaMurE + UML <br /> | ||
*MurF | *MurF | ||
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**[[2am1]], [[2am2]], [[3zm5]], [[3zm6]] – MurF + inhibitor – ''Streptococcus pneumoniae''<br /> | **[[2am1]], [[2am2]], [[3zm5]], [[3zm6]] – MurF + inhibitor – ''Streptococcus pneumoniae''<br /> | ||
**[[3zl8]] – TmMurF + ADP <br /> | **[[3zl8]] – TmMurF + ADP <br /> | ||
| - | + | **[[1gg4]] – EcMurF <br /> | |
| + | **[[3ddt]] – hMurF-1 ZF-B box + Zn – human <br /> | ||
| + | **[[2d8u]] – hMurF-1 ZF-B box + Zn - NMR<br /> | ||
| + | **[[4m3l]] – hMurF-1 coiled coil domain<br /> | ||
}} | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 08:53, 30 July 2017
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3D Structures of Mur ligase
Updated on 30-July-2017
References
- ↑ Munshi T, Gupta A, Evangelopoulos D, Guzman JD, Gibbons S, Keep NH, Bhakta S. Characterisation of ATP-dependent Mur ligases involved in the biogenesis of cell wall peptidoglycan in Mycobacterium tuberculosis. PLoS One. 2013;8(3):e60143. doi: 10.1371/journal.pone.0060143. Epub 2013 Mar 21. PMID:23555903 doi:http://dx.doi.org/10.1371/journal.pone.0060143
- ↑ Deva T, Baker EN, Squire CJ, Smith CA. Structure of Escherichia coli UDP-N-acetylmuramoyl:L-alanine ligase (MurC). Acta Crystallogr D Biol Crystallogr. 2006 Dec;62(Pt 12):1466-74. Epub 2006, Nov 23. PMID:17139082 doi:10.1107/S0907444906038376
- ↑ Perdih A, Hodoscek M, Solmajer T. MurD ligase from E. coli: Tetrahedral intermediate formation study by hybrid quantum mechanical/molecular mechanical replica path method. Proteins. 2009 Feb 15;74(3):744-59. doi: 10.1002/prot.22188. PMID:18704940 doi:http://dx.doi.org/10.1002/prot.22188
- ↑ . PMID:212153518
- ↑ Hrast M, Turk S, Sosic I, Knez D, Randall CP, Barreteau H, Contreras-Martel C, Dessen A, O'Neill AJ, Mengin-Lecreulx D, Blanot D, Gobec S. Structure-activity relationships of new cyanothiophene inhibitors of the essential peptidoglycan biosynthesis enzyme MurF. Eur J Med Chem. 2013 May 21;66C:32-45. doi: 10.1016/j.ejmech.2013.05.013. PMID:23786712 doi:10.1016/j.ejmech.2013.05.013
- ↑ Kouidmi I, Levesque RC, Paradis-Bleau C. The biology of Mur ligases as an antibacterial target. Mol Microbiol. 2014 Oct;94(2):242-53. doi: 10.1111/mmi.12758. Epub 2014 Sep 5. PMID:25130693 doi:http://dx.doi.org/10.1111/mmi.12758
- ↑ Bertrand JA, Auger G, Martin L, Fanchon E, Blanot D, Le Beller D, van Heijenoort J, Dideberg O. Determination of the MurD mechanism through crystallographic analysis of enzyme complexes. J Mol Biol. 1999 Jun 11;289(3):579-90. PMID:10356330 doi:10.1006/jmbi.1999.2800
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