Myosin light chain kinase

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{{STRUCTURE_2x4f| PDB=2x4f | SIZE=400| SCENE= |right|CAPTION=Two monomers of human myosin light chain kinase residues 40-388 complex with pyrimidine derivative, pentaethylene glycol, ethanediol and sulfate ion, [[2x4f]] }}
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<StructureSection load='2x4f' size='350' side='right' caption='Two monomers of human myosin light chain kinase residues 40-388 complex with pyrimidine derivative, pentaethylene glycol, ethanediol and sulfate ion (PDB entry [[2x4f]])' scene=''>
== Function ==
== Function ==
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== Disease ==
== Disease ==
A variant of MLCK is associated with severe asthma in African Americans<ref>PMID:17266121</ref>. Epithelial MLCK is critical for intestinal barrier dysfunction and hence for pathogenesis of diarrheal diseases<ref>PMID:16184195</ref>.
A variant of MLCK is associated with severe asthma in African Americans<ref>PMID:17266121</ref>. Epithelial MLCK is critical for intestinal barrier dysfunction and hence for pathogenesis of diarrheal diseases<ref>PMID:16184195</ref>.
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</StructureSection>
==3D structures of MLCK==
==3D structures of MLCK==

Revision as of 08:44, 31 July 2017

Two monomers of human myosin light chain kinase residues 40-388 complex with pyrimidine derivative, pentaethylene glycol, ethanediol and sulfate ion (PDB entry 2x4f)

Drag the structure with the mouse to rotate

3D structures of MLCK

2cqv – hMLCK 8th Ig-like domain – human – NMR
2yr3 - hMLCK 4th Ig-like domain – NMR
2x4f – hMLCK residues 40-388

References

  1. ↑ Stull JT, Tansey MG, Tang DC, Word RA, Kamm KE. Phosphorylation of myosin light chain kinase: a cellular mechanism for Ca2+ desensitization. Mol Cell Biochem. 1993 Nov;127-128:229-37. PMID:7935354
  2. ↑ Flores C, Ma SF, Maresso K, Ober C, Garcia JG. A variant of the myosin light chain kinase gene is associated with severe asthma in African Americans. Genet Epidemiol. 2007 May;31(4):296-305. PMID:17266121 doi:http://dx.doi.org/10.1002/gepi.20210
  3. ↑ Clayburgh DR, Barrett TA, Tang Y, Meddings JB, Van Eldik LJ, Watterson DM, Clarke LL, Mrsny RJ, Turner JR. Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivo. J Clin Invest. 2005 Oct;115(10):2702-15. Epub 2005 Sep 22. PMID:16184195 doi:http://dx.doi.org/10.1172/JCI24970

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Michal Harel, Alexander Berchansky

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