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5ifh
From Proteopedia
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ifh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ifh OCA], [http://pdbe.org/5ifh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ifh RCSB], [http://www.ebi.ac.uk/pdbsum/5ifh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ifh ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ifh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ifh OCA], [http://pdbe.org/5ifh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ifh RCSB], [http://www.ebi.ac.uk/pdbsum/5ifh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ifh ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Cell-autonomous B-cell receptor (BcR)-mediated signalling is a hallmark feature of the neoplastic B lymphocytes in chronic lymphocytic leukaemia (CLL). Here we elucidate the structural basis of autonomous activation of CLL B cells, showing that BcR immunoglobulins initiate intracellular signalling through homotypic interactions between epitopes that are specific for each subgroup of patients with homogeneous clinicobiological profiles. The molecular details of the BcR-BcR interactions apparently dictate the clinical course of disease, with stronger affinities and longer half-lives in indolent cases, and weaker, short-lived contacts mediating the aggressive ones. The diversity of homotypic BcR contacts leading to cell-autonomous signalling reconciles the existence of a shared pathogenic mechanism with the biological and clinical heterogeneity of CLL and offers opportunities for innovative treatment strategies. | ||
| + | |||
| + | Distinct homotypic B-cell receptor interactions shape the outcome of chronic lymphocytic leukaemia.,Minici C, Gounari M, Ubelhart R, Scarfo L, Duhren-von Minden M, Schneider D, Tasdogan A, Alkhatib A, Agathangelidis A, Ntoufa S, Chiorazzi N, Jumaa H, Stamatopoulos K, Ghia P, Degano M Nat Commun. 2017 Jun 9;8:15746. doi: 10.1038/ncomms15746. PMID:28598442<ref>PMID:28598442</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 5ifh" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 07:58, 3 August 2017
Crystal structure of the BCR Fab fragment from subset #2 case P11475
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