5l6q
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Refolded AL protein from cardiac amyloidosis== | |
| + | <StructureSection load='5l6q' size='340' side='right' caption='[[5l6q]], [[Resolution|resolution]] 1.40Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5l6q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L6Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L6Q FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4od2|4od2]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l6q OCA], [http://pdbe.org/5l6q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l6q RCSB], [http://www.ebi.ac.uk/pdbsum/5l6q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l6q ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Systemic amyloidosis is caused by the misfolding of a circulating amyloid precursor protein and the deposition of amyloid fibrils in multiple organs. Chemical and biophysical analysis of amyloid fibrils from human AL and murine AA amyloidosis reveal the same fibril morphologies in different tissues or organs of one patient or diseased animal. The observed structural similarities concerned the fibril morphology, the fibril protein primary and secondary structures, the presence of post-translational modifications and, in case of the AL fibrils, the partially folded characteristics of the polypeptide chain within the fibril. Our data imply for both analyzed forms of amyloidosis that the pathways of protein misfolding are systemically conserved; that is, they follow the same rules irrespective of where inside one body fibrils are formed or accumulated. | ||
| - | + | Common Fibril Structures Imply Systemically Conserved Protein Misfolding Pathways In Vivo.,Annamalai K, Liberta F, Vielberg MT, Close W, Lilie H, Guhrs KH, Schierhorn A, Koehler R, Schmidt A, Haupt C, Hegenbart U, Schonland S, Schmidt M, Groll M, Fandrich M Angew Chem Int Ed Engl. 2017 Jun 19;56(26):7510-7514. doi:, 10.1002/anie.201701761. Epub 2017 May 23. PMID:28544119<ref>PMID:28544119</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 5l6q" style="background-color:#fffaf0;"></div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | [[Category: Homo sapiens]] | |
| - | + | ||
| - | + | ||
| - | [[Category: | + | |
[[Category: Annamalai, K]] | [[Category: Annamalai, K]] | ||
| + | [[Category: Faendrich, M]] | ||
[[Category: Groll, M]] | [[Category: Groll, M]] | ||
| + | [[Category: Guehrs, K H]] | ||
| + | [[Category: Haupt, C]] | ||
| + | [[Category: Hegenbart, O]] | ||
[[Category: Koehler, R]] | [[Category: Koehler, R]] | ||
| + | [[Category: Liberta, F]] | ||
[[Category: Lilie, H]] | [[Category: Lilie, H]] | ||
| + | [[Category: Schierhorn, A]] | ||
| + | [[Category: Schmidt, A]] | ||
| + | [[Category: Schoenland, S]] | ||
| + | [[Category: Vielberg, M T]] | ||
| + | [[Category: Amyloid fibril]] | ||
| + | [[Category: Antibody]] | ||
| + | [[Category: Immune system]] | ||
| + | [[Category: Light chain]] | ||
| + | [[Category: Systemic al amyloidosis]] | ||
Revision as of 08:20, 3 August 2017
Refolded AL protein from cardiac amyloidosis
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