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1o7b

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Revision as of 08:34, 3 August 2017

Refined solution structure of the human TSG-6 Link module

Structural highlights

1o7b is a 1 chain structure. This structure supersedes the now removed PDB entry 1tsg. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Related:	1tsg, 1o7c
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[TSG6_HUMAN] Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The solution structure of the Link module from human TSG-6, a hyaladherin with important roles in inflammation and ovulation, has been determined in both its free and hyaluronan-bound conformations. This reveals a well defined hyaluronan-binding groove on one face of the Link module that is closed in the absence of ligand. The groove is lined with amino acids that have been implicated in mediating the interaction with hyaluronan, including two tyrosine residues that appear to form essential intermolecular hydrogen bonds and two basic residues capable of supporting ionic interactions. This is the first structure of a non-enzymic hyaladherin in its active state, and identifies a ligand-induced conformational change that is likely to be conserved across the Link module superfamily. NMR and isothermal titration calorimetry experiments with defined oligosaccharides have allowed us to infer the minimum length of hyaluronan that can be accommodated within the binding site and its polarity in the groove; these data have been used to generate a model of the complex formed between the Link module and a hyaluronan octasaccharide.

The link module from ovulation- and inflammation-associated protein TSG-6 changes conformation on hyaluronan binding.,Blundell CD, Mahoney DJ, Almond A, DeAngelis PL, Kahmann JD, Teriete P, Pickford AR, Campbell ID, Day AJ J Biol Chem. 2003 Dec 5;278(49):49261-70. Epub 2003 Sep 11. PMID:12972412^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Blundell CD, Mahoney DJ, Almond A, DeAngelis PL, Kahmann JD, Teriete P, Pickford AR, Campbell ID, Day AJ. The link module from ovulation- and inflammation-associated protein TSG-6 changes conformation on hyaluronan binding. J Biol Chem. 2003 Dec 5;278(49):49261-70. Epub 2003 Sep 11. PMID:12972412 doi:http://dx.doi.org/10.1074/jbc.M309623200

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1o7b"

@@ Line 1: / Line 1: @@
-==REFINED SOLUTION STRUCTURE OF THE HUMAN TSG-6 LINK MODULE==
+==Refined solution structure of the human TSG-6 Link module==
 <StructureSection load='1o7b' size='340' side='right' caption='[[1o7b]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1o7b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1tsg 1tsg]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O7B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1O7B FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1o7b]] is a 1 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1tsg 1tsg]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O7B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1O7B FirstGlance]. <br>
 </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1tsg|1tsg]], [[1o7c|1o7c]]</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1o7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o7b OCA], [http://pdbe.org/1o7b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1o7b RCSB], [http://www.ebi.ac.uk/pdbsum/1o7b PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1o7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o7b OCA], [http://pdbe.org/1o7b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1o7b RCSB], [http://www.ebi.ac.uk/pdbsum/1o7b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1o7b ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 31: / Line 32: @@
 __TOC__
 </StructureSection>
-[[Category: Human]]
 [[Category: Blundell, C D]]
 [[Category: Campbell, I D]]

1o7b

From Proteopedia

Revision as of 08:34, 3 August 2017

Refined solution structure of the human TSG-6 Link module

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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