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1jw6

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Revision as of 08:57, 3 August 2017

Crystal Structure of the Complex of Concanavalin A and Hexapeptide

Structural highlights

1jw6 is a 2 chain structure with sequence from Canavalia ensiformis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	, , ,
Related:	1hqw
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[CONA_CANEN] D-mannose specific lectin.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The X-ray structure analysis of a cross-linked crystal of concanavalin A soaked with a hexapeptide molecule as a probe molecule showed an electron density corresponding to full occupation in the binding pocket. The site lies on the surface of concanavalin A and is surrounded by three symmetry-related molecules. The crystal structure of the hexapeptide complex was refined at 1.93-A resolution, to an R-factor of 19% (Rfree factor of 25%), with an RMS deviation in bond distances of 0.01 A. The model includes all 237 residues of concanavalin A, one manganese ion, one calcium ion, 95 water molecules, one glutaraldehyde molecule, one isopropanol molecule, and one hexapeptide molecule. This X-ray structure analysis also provides an approach to mapping the binding surface of crystalline protein with a probe molecule that is dissolved in the mixture of organic solvent with water or in neat organic solvent but is hardly dissolved in aqueous solution.

Crystal structure of the complex of concanavalin A and hexapeptide.,Zhang Z, Qian M, Huang Q, Jia Y, Tang Y, Wang K, Cui D, Li M J Protein Chem. 2001 Jul;20(5):423-9. PMID:11732694^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Zhang Z, Qian M, Huang Q, Jia Y, Tang Y, Wang K, Cui D, Li M. Crystal structure of the complex of concanavalin A and hexapeptide. J Protein Chem. 2001 Jul;20(5):423-9. PMID:11732694

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1jw6"

@@ Line 1: / Line 1: @@
 ==Crystal Structure of the Complex of Concanavalin A and Hexapeptide==
 <StructureSection load='1jw6' size='340' side='right' caption='[[1jw6]], [[Resolution|resolution]] 1.93&Aring;' scene=''>
@@ Line 5: / Line 6: @@
 </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PTD:PENTANEDIAL'>PTD</scene></td></tr>
 <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1hqw|1hqw]]</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jw6 OCA], [http://pdbe.org/1jw6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jw6 RCSB], [http://www.ebi.ac.uk/pdbsum/1jw6 PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jw6 OCA], [http://pdbe.org/1jw6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jw6 RCSB], [http://www.ebi.ac.uk/pdbsum/1jw6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1jw6 ProSAT]</span></td></tr>
 </table>
 == Function ==

1jw6

From Proteopedia

Revision as of 08:57, 3 August 2017

Crystal Structure of the Complex of Concanavalin A and Hexapeptide

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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