5mpt
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mpt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mpt OCA], [http://pdbe.org/5mpt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mpt RCSB], [http://www.ebi.ac.uk/pdbsum/5mpt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mpt ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mpt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mpt OCA], [http://pdbe.org/5mpt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mpt RCSB], [http://www.ebi.ac.uk/pdbsum/5mpt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mpt ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CITS_MONPU CITS_MONPU]] Non-reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of the mycotoxin citrinin, a hepato-nephrotoxic compound to humans due to inhibition of respiration complex III (PubMed:16000748, PubMed:19012408, PubMed:19111642, PubMed:27913218, PubMed:28238725). The pathway begins with the synthesis of a keto-aldehyde intermediate by the citrinin PKS (pksCT) from successive condensations of 4 malonyl-CoA units, presumably with a simple acetyl-CoA starter unit (PubMed:28238725). Release of the keto-aldehyde intermediate is consistent with the presence of the C-terminal reductive release domain (PubMed:28238725). The exact catalytic role of the hydrolase mpl1 remains mysterious, although it is clear that it increases the productivity of the PKS and performs the earliest non-PKS step during citrinin biosynthesis (PubMed:27913218). Mpl2 then catalyzes the oxidation of the C-12 methyl of the ketone intermediate to an alcohol intermediate which is further oxidized by the oxidoreductase mpl7 to produce a bisaldehyde intermediate (PubMed:27913218). The fourth catalytic step is catalyzed by the mpl4 aldehyde dehydrogenase (PubMed:27913218). The final transformation is the reduction of C-3 by mpl6 to provide the chemically stable citrinin nucleus (PubMed:27913218).<ref>PMID:16000748</ref> <ref>PMID:19012408</ref> <ref>PMID:19111642</ref> <ref>PMID:27913218</ref> <ref>PMID:28238725</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Revision as of 09:53, 3 August 2017
Structure of the citrinin polyketide synthase CMeT domain
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