5mxt
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mxt OCA], [http://pdbe.org/5mxt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mxt RCSB], [http://www.ebi.ac.uk/pdbsum/5mxt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mxt ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mxt OCA], [http://pdbe.org/5mxt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mxt RCSB], [http://www.ebi.ac.uk/pdbsum/5mxt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mxt ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Certain cationic peptides interact with biological membranes. These often-complex interactions can result in peptide targeting to the membrane, or in membrane permeation, rupture, and cell lysis. We investigated the relationship between the structural features of membrane-active peptides and these effects, to better understand these processes. To this end, we employed a computational method for morphing a membranolytic antimicrobial peptide into a nonmembranolytic mitochondrial targeting peptide by "directed simulated evolution." The results obtained demonstrate that superficially subtle sequence modifications can strongly affect the peptides' membranolytic and membrane-targeting abilities. Spectroscopic and computational analyses suggest that N- and C-terminal structural flexibility plays a crucial role in determining the mode of peptide-membrane interaction. | ||
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| + | Peptide-Membrane Interaction between Targeting and Lysis.,Stutz K, Muller AT, Hiss JA, Schneider P, Blatter M, Pfeiffer B, Posselt G, Kanfer G, Kornmann B, Wrede P, Altmann KH, Wessler S, Schneider G ACS Chem Biol. 2017 Aug 8. doi: 10.1021/acschembio.7b00504. PMID:28763193<ref>PMID:28763193</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 5mxt" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 09:05, 9 August 2017
Peptide-membrane interaction between targeting and lysis
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