1w45
From Proteopedia
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| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w45 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w45 OCA], [http://www.ebi.ac.uk/pdbsum/1w45 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1w45 RCSB]</span> | ||
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[[Category: intact n-terminus]] | [[Category: intact n-terminus]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:30:54 2008'' |
Revision as of 21:30, 30 March 2008
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| , resolution 2.51Å | |||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
THE 2.5 ANGSTROEM STRUCTURE OF THE K16A MUTANT OF ANNEXIN A8, WHICH HAS AN INTACT N-TERMINUS.
Overview
Annexin A8 is a relatively infrequent and poorly studied member of this large family of calcium-binding and membrane-binding proteins. It is, however, associated with a specific disease, acute promyelocytic leukemia. We have solved its three-dimensional structure, which includes a moderately long and intact N terminus. The structure is closest to that of annexin A3 and highlights several important regions of inherent flexibility in the annexin molecule. The N terminus resembles that of annexin A3, as it lies along the concave surface of the molecule and inserts partially into the hydrophilic channel in its centre. Since both annexins A3 and A8 are expressed in promyelocytic cells during their differentiation, the similarity in their structures might suggest a functional relationship.
About this Structure
1W45 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The crystal structure of annexin A8 is similar to that of annexin A3., Rety S, Sopkova-de Oliveira Santos J, Dreyfuss L, Blondeau K, Hofbauerova K, Raguenes-Nicol C, Kerboeuf D, Renouard M, Russo-Marie F, Lewit-Bentley A, J Mol Biol. 2005 Feb 4;345(5):1131-9. Epub 2004 Dec 8. PMID:15644210
Page seeded by OCA on Mon Mar 31 00:30:54 2008
Categories: Homo sapiens | Single protein | Blondeau, K. | Dreyfuss, L. | Hofbauerova, K. | Lewit-Bentley, A. | Raguenes-Nicol, C. | Renouard, M. | Rety, S. | Russo-Marie, F. | Santos, J Sopkova-De Oliveira. | Annexin family | Calcium and phospholipid binding protein | Coagulation | Cxalcium and membrane-binding protein | Intact n-terminus
