1w3z

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|PDB= 1w3z |SIZE=350|CAPTION= <scene name='initialview01'>1w3z</scene>, resolution 3.2&Aring;
|PDB= 1w3z |SIZE=350|CAPTION= <scene name='initialview01'>1w3z</scene>, resolution 3.2&Aring;
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|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w3z OCA], [http://www.ebi.ac.uk/pdbsum/1w3z PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1w3z RCSB]</span>
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[[Category: tick]]
[[Category: tick]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:51:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:30:56 2008''

Revision as of 21:30, 30 March 2008


PDB ID 1w3z

Drag the structure with the mouse to rotate
, resolution 3.2Å
Ligands:
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



SEMET DERIVATIVE OF BBCRASP-1 FROM BORRELIA BURGDORFERI


Overview

Borrelia burgdorferi, a spirochete transmitted to human hosts during feeding of infected Ixodes ticks, is the causative agent of Lyme disease. Serum-resistant B. burgdorferi strains cause a chronic, multisystemic form of the disease and bind complement factor H (FH) and FH-like protein 1 (FHL-1) on the spirochete surface. Here we report the atomic structure for the key FHL-1- and FH-binding protein BbCRASP-1 and reveal a homodimer that presents a novel target for drug design.

About this Structure

1W3Z is a Single protein structure of sequence from Borrelia burgdorferi. Full crystallographic information is available from OCA.

Reference

A novel fold for the factor H-binding protein BbCRASP-1 of Borrelia burgdorferi., Cordes FS, Roversi P, Kraiczy P, Simon MM, Brade V, Jahraus O, Wallis R, Skerka C, Zipfel PF, Wallich R, Lea SM, Nat Struct Mol Biol. 2005 Mar;12(3):276-7. Epub 2005 Feb 13. PMID:15711564

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