Lignin peroxidase
From Proteopedia
(Difference between revisions)
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| - | <StructureSection load='3q3u' size=' | + | <StructureSection load='3q3u' size='450' side='right' caption='Lignin peroxidase containing heme complex with MPD, Ca+2 (large green), Na+ (purple) and Cl- (small green) ions (PDB entry [[3q3u]])' scene='48/486472/Cv/1'> |
== Function == | == Function == | ||
'''Lignin peroxidase''' (Lip) catalyzes the biodegradation of lignin using hydrogen peroxide. Lignin comprises 20-30% of woody plants cell wall. It is made of branched and heterogenous structure of phenylpropanoid units. It is highly resistant to biodegradation and only higher fungi are capable of degrading it. Veratryl alcohol is the cofactor in this reaction<ref>PMID:9790672</ref>. | '''Lignin peroxidase''' (Lip) catalyzes the biodegradation of lignin using hydrogen peroxide. Lignin comprises 20-30% of woody plants cell wall. It is made of branched and heterogenous structure of phenylpropanoid units. It is highly resistant to biodegradation and only higher fungi are capable of degrading it. Veratryl alcohol is the cofactor in this reaction<ref>PMID:9790672</ref>. | ||
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== Relevance == | == Relevance == | ||
Lip is used as a skin-lightening active agent<ref>PMID:25574195</ref>. | Lip is used as a skin-lightening active agent<ref>PMID:25574195</ref>. | ||
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| + | == Structural highlights == | ||
| + | *<scene name='48/486472/Cv/3'>Heme binding site</scene>. | ||
| + | *<scene name='48/486472/Cv/4'>Fe coordination site</scene>. | ||
| + | *<scene name='48/486472/Cv/5'>Cl coordination site</scene>. | ||
| + | *<scene name='48/486472/Cv/6'>1st Ca coordination site</scene>. | ||
| + | *<scene name='48/486472/Cv/7'>2nd Ca coordination site</scene>. | ||
</StructureSection> | </StructureSection> | ||
==3D structures of lignin peroxidase== | ==3D structures of lignin peroxidase== | ||
Revision as of 14:08, 9 August 2017
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3D structures of lignin peroxidase
1lga, 1llp, 1qpa, 1b80, 1b82 – PcLip – Phanerochaete chrysosporium
1b85 – PcLip (mutant)
3q3u – Lip – Trametes cervina
References
- ↑ Doyle WA, Blodig W, Veitch NC, Piontek K, Smith AT. Two substrate interaction sites in lignin peroxidase revealed by site-directed mutagenesis. Biochemistry. 1998 Oct 27;37(43):15097-105. PMID:9790672 doi:http://dx.doi.org/10.1021/bi981633h
- ↑ Zhong SM, Sun N, Liu HX, Niu YQ, Wu Y. Reduction of facial pigmentation of melasma by topical lignin peroxidase: A novel fast-acting skin-lightening agent. Exp Ther Med. 2015 Feb;9(2):341-344. Epub 2014 Dec 8. PMID:25574195 doi:http://dx.doi.org/10.3892/etm.2014.2118
