1w6s
From Proteopedia
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|PDB= 1w6s |SIZE=350|CAPTION= <scene name='initialview01'>1w6s</scene>, resolution 1.2Å | |PDB= 1w6s |SIZE=350|CAPTION= <scene name='initialview01'>1w6s</scene>, resolution 1.2Å | ||
|SITE= <scene name='pdbsite=AC1:Ca+Binding+Site+For+Chain+C'>AC1</scene> | |SITE= <scene name='pdbsite=AC1:Ca+Binding+Site+For+Chain+C'>AC1</scene> | ||
| - | |LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PQQ:PYRROLOQUINOLINE+QUINONE'>PQQ</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Alcohol_dehydrogenase_(acceptor) Alcohol dehydrogenase (acceptor)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.99.8 1.1.99.8] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Alcohol_dehydrogenase_(acceptor) Alcohol dehydrogenase (acceptor)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.99.8 1.1.99.8] </span> |
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w6s OCA], [http://www.ebi.ac.uk/pdbsum/1w6s PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1w6s RCSB]</span> | ||
}} | }} | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1W6S is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ | + | 1W6S is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Thermomicrobium_roseum Thermomicrobium roseum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W6S OCA]. |
==Reference== | ==Reference== | ||
The atomic resolution structure of methanol dehydrogenase from Methylobacterium extorquens., Williams PA, Coates L, Mohammed F, Gill R, Erskine PT, Coker A, Wood SP, Anthony C, Cooper JB, Acta Crystallogr D Biol Crystallogr. 2005 Jan;61(Pt 1):75-9. Epub 2004 Dec, 17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15608378 15608378] | The atomic resolution structure of methanol dehydrogenase from Methylobacterium extorquens., Williams PA, Coates L, Mohammed F, Gill R, Erskine PT, Coker A, Wood SP, Anthony C, Cooper JB, Acta Crystallogr D Biol Crystallogr. 2005 Jan;61(Pt 1):75-9. Epub 2004 Dec, 17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15608378 15608378] | ||
[[Category: Alcohol dehydrogenase (acceptor)]] | [[Category: Alcohol dehydrogenase (acceptor)]] | ||
| - | [[Category: Methylobacterium extorquens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| + | [[Category: Thermomicrobium roseum]] | ||
[[Category: Anthony, C.]] | [[Category: Anthony, C.]] | ||
[[Category: Coates, L.]] | [[Category: Coates, L.]] | ||
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[[Category: Williams, P A.]] | [[Category: Williams, P A.]] | ||
[[Category: Wood, S P.]] | [[Category: Wood, S P.]] | ||
| - | + | [[Category: anisotropic,electron transfer]] | |
| - | + | ||
| - | + | ||
| - | [[Category: anisotropic]] | + | |
[[Category: calcium-binding]] | [[Category: calcium-binding]] | ||
| - | [[Category: electron transfer]] | ||
[[Category: methanol utilization]] | [[Category: methanol utilization]] | ||
[[Category: oxidoreductase]] | [[Category: oxidoreductase]] | ||
[[Category: pqq]] | [[Category: pqq]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:32:00 2008'' |
Revision as of 21:32, 30 March 2008
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| , resolution 1.2Å | |||||||
|---|---|---|---|---|---|---|---|
| Sites: | |||||||
| Ligands: | , , | ||||||
| Activity: | Alcohol dehydrogenase (acceptor), with EC number 1.1.99.8 | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
THE HIGH RESOLUTION STRUCTURE OF METHANOL DEHYDROGENASE FROM METHYLOBACTERIUM EXTORQUENS
Overview
The crystal structure of methanol dehydrogenase (MDH) from Methylobacterium extorquens has been refined without stereochemical restraints at a resolution of 1.2 A. The high-resolution data have defined the conformation of the tricyclic pyrroloquinoline quinone (PQQ) cofactor ring as entirely planar. The detailed definition of the active-site geometry has shown many features that are similar to the quinohaemo-protein alcohol dehydrogenases from Comamonas testosteroni and Pseudomonas putida, both of which possess MDH-like and cytochrome c-like domains. Conserved features between the two types of PQQ-containing enzyme suggest a common pathway for electron transfer between MDH and its physiological electron acceptor cytochrome cL. A pathway for proton transfer from the active site to the bulk solvent is also suggested.
About this Structure
1W6S is a Protein complex structure of sequences from Thermomicrobium roseum. Full crystallographic information is available from OCA.
Reference
The atomic resolution structure of methanol dehydrogenase from Methylobacterium extorquens., Williams PA, Coates L, Mohammed F, Gill R, Erskine PT, Coker A, Wood SP, Anthony C, Cooper JB, Acta Crystallogr D Biol Crystallogr. 2005 Jan;61(Pt 1):75-9. Epub 2004 Dec, 17. PMID:15608378
Page seeded by OCA on Mon Mar 31 00:32:00 2008
