4p8h
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of M. tuberculosis DprE1 in complex with the nitro-benzothiazole 6a== | |
| - | + | <StructureSection load='4p8h' size='340' side='right' caption='[[4p8h]], [[Resolution|resolution]] 3.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4p8h]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P8H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P8H FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=O95:{(4S)-2-[7-(HYDROXYAMINO)-6-METHYL-5-(TRIFLUOROMETHYL)-1,3-BENZOTHIAZOL-2-YL]-4,5-DIHYDRO-1,3-OXAZOL-4-YL}(PYRROLIDIN-1-YL)METHANONE'>O95</scene></td></tr> | |
| - | [[ | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4p8c|4p8c]], [[4p8k|4p8k]], [[4p8l|4p8l]], [[4p8m|4p8m]], [[4p8n|4p8n]], [[4p8p|4p8p]], [[4p8t|4p8t]], [[4p8y|4p8y]]</td></tr> |
| - | [[Category: Cole, S | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p8h OCA], [http://pdbe.org/4p8h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4p8h RCSB], [http://www.ebi.ac.uk/pdbsum/4p8h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4p8h ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/DPRE1_MYCTU DPRE1_MYCTU]] Involved in the epimerization of decaprenylphosphoryl ribose (DPR) to decaprenylphosphoryl arabinose (DPA) a precursor for arabinan synthesis in mycobacterial cell wall biosynthesis. Probably catalyzes the oxidation at C-2 of decaprenylphosphoryl ribose (DPR) to yield decaprenylphosphoryl 2-keto-ribose (DPX).<ref>PMID:16291675</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Cole, S T]] | ||
[[Category: Neres, J]] | [[Category: Neres, J]] | ||
| + | [[Category: Complex]] | ||
| + | [[Category: Covalent]] | ||
| + | [[Category: Dpre1]] | ||
| + | [[Category: Inhibitor]] | ||
| + | [[Category: Nitro-benzothiazole 6a]] | ||
| + | [[Category: Oxidoreductase-oxidoreductase inhibitor complex]] | ||
Revision as of 17:16, 18 August 2017
Crystal structure of M. tuberculosis DprE1 in complex with the nitro-benzothiazole 6a
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