This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
5mx9
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==High resolution crystal structure of the MCR-2 catalytic domain== | |
| + | <StructureSection load='5mx9' size='340' side='right' caption='[[5mx9]], [[Resolution|resolution]] 1.12Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5mx9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MX9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MX9 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mx9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mx9 OCA], [http://pdbe.org/5mx9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mx9 RCSB], [http://www.ebi.ac.uk/pdbsum/5mx9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mx9 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | MCR-2 confers resistance to colistin, a `last-line' antibiotic against extensively resistant Gram-negative pathogens. It is a plasmid-encoded phosphoethanolamine transferase that is closely related to MCR-1. To understand the diversity in the MCR family, the 1.12 A resolution crystal structure of the catalytic domain of MCR-2 was determined. Variable amino acids are located distant from both the di-zinc active site and the membrane-proximal face. The exceptionally high resolution will provide an accurate starting model for further mechanistic studies. | ||
| - | + | 1.12 A resolution crystal structure of the catalytic domain of the plasmid-mediated colistin resistance determinant MCR-2.,Coates K, Walsh TR, Spencer J, Hinchliffe P Acta Crystallogr F Struct Biol Commun. 2017 Aug 1;73(Pt 8):443-449. doi:, 10.1107/S2053230X17009669. Epub 2017 Jul 26. PMID:28777086<ref>PMID:28777086</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 5mx9" style="background-color:#fffaf0;"></div> | |
| - | + | == References == | |
| - | + | <references/> | |
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Coates, K]] | [[Category: Coates, K]] | ||
| + | [[Category: Hinchliffe, P]] | ||
| + | [[Category: Spencer, J]] | ||
| + | [[Category: Walsh, T R]] | ||
| + | [[Category: Antibiotic resistance]] | ||
| + | [[Category: Colistin]] | ||
| + | [[Category: Mcr-1]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 10:59, 24 August 2017
High resolution crystal structure of the MCR-2 catalytic domain
| |||||||||||
