Pantothenate synthetase
From Proteopedia
(Difference between revisions)
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**[[5hg0]] - FtPS + SAM – ''Francisella tularensis''<br /> | **[[5hg0]] - FtPS + SAM – ''Francisella tularensis''<br /> | ||
| - | *Pantothenate synthetase complex with adenosine derivatives | + | *Pantothenate synthetase binary complex with adenosine derivatives |
**[[1n2g]] - MtPS + AMPCPP <br /> | **[[1n2g]] - MtPS + AMPCPP <br /> | ||
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**[[3iob]], [[3ioc]], [[3iod]], [[3ioe]] - MtPS (mutant) + adenosine derivative<br /> | **[[3iob]], [[3ioc]], [[3iod]], [[3ioe]] - MtPS (mutant) + adenosine derivative<br /> | ||
**[[5kwv]] – NgPS (mutant) + AMPPNP – ''Neisseria gonorrhoeae''<br /> | **[[5kwv]] – NgPS (mutant) + AMPPNP – ''Neisseria gonorrhoeae''<br /> | ||
| - | **[[5ucr]] – NgPS (mutant) + AMP + alanine<br /> | ||
*Pantothenate synthetase binary complex with pantoate derivatives | *Pantothenate synthetase binary complex with pantoate derivatives | ||
| - | **[[1n2i]] - MtPS (mutant) + pantoyl adenylate<br /> | + | **[[1n2i]], [[1n2h]] - MtPS (mutant) + pantoyl adenylate<br /> |
**[[1n2j]] - MtPS (mutant) + pantoate<br /> | **[[1n2j]] - MtPS (mutant) + pantoate<br /> | ||
**[[1n2o]] - MtPS (mutant) + β-alanine<br /> | **[[1n2o]] - MtPS (mutant) + β-alanine<br /> | ||
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**[[2a86]] - MtPS (mutant) + β-alanine + AMP<br /> | **[[2a86]] - MtPS (mutant) + β-alanine + AMP<br /> | ||
| + | **[[5ucr]] – NgPS (mutant) + AMP + alanine<br /> | ||
**[[4g5y]] - MtPS (mutant) + thiophene derivative + ATP<br /> | **[[4g5y]] - MtPS (mutant) + thiophene derivative + ATP<br /> | ||
**[[3uy4]] - CjPS + pantothenate + AMP<br /> | **[[3uy4]] - CjPS + pantothenate + AMP<br /> | ||
Revision as of 10:19, 29 August 2017
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3D structures of pantothenate synthetase
Updated on 29-August-2017
References
- ↑ Jonczyk R, Ronconi S, Rychlik M, Genschel U. Pantothenate synthetase is essential but not limiting for pantothenate biosynthesis in Arabidopsis. Plant Mol Biol. 2008 Jan;66(1-2):1-14. Epub 2007 Oct 12. PMID:17932772 doi:http://dx.doi.org/10.1007/s11103-007-9248-6
- ↑ Hung AW, Silvestre HL, Wen S, George GP, Boland J, Blundell TL, Ciulli A, Abell C. Optimization of Inhibitors of Mycobacterium tuberculosis Pantothenate Synthetase Based on Group Efficiency Analysis. ChemMedChem. 2016 Jan 5;11(1):38-42. doi: 10.1002/cmdc.201500414. Epub 2015 Oct, 21. PMID:26486566 doi:http://dx.doi.org/10.1002/cmdc.201500414
- ↑ Wang S, Eisenberg D. Crystal structures of a pantothenate synthetase from M. tuberculosis and its complexes with substrates and a reaction intermediate. Protein Sci. 2003 May;12(5):1097-108. PMID:12717031
