5iv5
From Proteopedia
(Difference between revisions)
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5iv5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iv5 OCA], [http://pdbe.org/5iv5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5iv5 RCSB], [http://www.ebi.ac.uk/pdbsum/5iv5 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5iv5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iv5 OCA], [http://pdbe.org/5iv5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5iv5 RCSB], [http://www.ebi.ac.uk/pdbsum/5iv5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5iv5 ProSAT]</span></td></tr> |
</table> | </table> | ||
{{Large structure}} | {{Large structure}} | ||
== Function == | == Function == | ||
| - | [[http://www.uniprot.org/uniprot/BP11_BPT4 BP11_BPT4]] Baseplate protein that is part of the baseplate wedge and that connects the short tail fibers to the baseplate (PubMed:15315755). Involved in the tail assembly.<ref>PMID:15315755</ref> <ref>PMID:21129200</ref> [[http://www.uniprot.org/uniprot/BP53_BPT4 BP53_BPT4]] Baseplate protein that is part of the baseplate wedge (PubMed:15315755). Involved in the tail assembly.<ref>PMID:15315755</ref> <ref>PMID:21129200</ref> [[http://www.uniprot.org/uniprot/BP08_BPT4 BP08_BPT4]] Baseplate protein that is part of the baseplate wedge. Involved in the tail assembly.<ref>PMID:15315755</ref> <ref>PMID:21129200</ref> [[http://www.uniprot.org/uniprot/FIB12_BPT4 FIB12_BPT4]] Structural component of the short tail fiber. Adhesion protein that binds irreversibly to the lipopolysaccharides component (LPS) on the cell surface of Escherichia coli B strains during virus attachment. After at least three long tail fibers have bound, short tail fibers extend and bind irreversibly to the core region of the host cell LPS.<ref>PMID:12837775</ref> [[http://www.uniprot.org/uniprot/BP25_BPT4 BP25_BPT4]] Baseplate protein that is part of the outer wedges of the baseplate (PubMed:15315755). Probably plays a role as a connector between the central and peripheral parts of the baseplate. Involved in the tail assembly.[UniProtKB:P51768]<ref>PMID:15315755</ref> <ref>PMID:21129200</ref> [[http://www.uniprot.org/uniprot/ | + | [[http://www.uniprot.org/uniprot/BP11_BPT4 BP11_BPT4]] Baseplate protein that is part of the baseplate wedge and that connects the short tail fibers to the baseplate (PubMed:15315755). Involved in the tail assembly.<ref>PMID:15315755</ref> <ref>PMID:21129200</ref> [[http://www.uniprot.org/uniprot/BP53_BPT4 BP53_BPT4]] Baseplate protein that is part of the baseplate wedge (PubMed:15315755). Involved in the tail assembly.<ref>PMID:15315755</ref> <ref>PMID:21129200</ref> [[http://www.uniprot.org/uniprot/BP08_BPT4 BP08_BPT4]] Baseplate protein that is part of the baseplate wedge. Involved in the tail assembly.<ref>PMID:15315755</ref> <ref>PMID:21129200</ref> [[http://www.uniprot.org/uniprot/FIB12_BPT4 FIB12_BPT4]] Structural component of the short tail fiber. Adhesion protein that binds irreversibly to the lipopolysaccharides component (LPS) on the cell surface of Escherichia coli B strains during virus attachment. After at least three long tail fibers have bound, short tail fibers extend and bind irreversibly to the core region of the host cell LPS.<ref>PMID:12837775</ref> [[http://www.uniprot.org/uniprot/BP25_BPT4 BP25_BPT4]] Baseplate protein that is part of the outer wedges of the baseplate (PubMed:15315755). Probably plays a role as a connector between the central and peripheral parts of the baseplate. Involved in the tail assembly.[UniProtKB:P51768]<ref>PMID:15315755</ref> <ref>PMID:21129200</ref> [[http://www.uniprot.org/uniprot/BP54_BPT4 BP54_BPT4]] Baseplate protein that is part of the baseplate-tail tube junction. Morphogenesis of the baseplate is completed by association of gp48 and gp54, allowing the initiation of the tail-tube polymerization. Involved in the tail assembly.<ref>PMID:3363870</ref> <ref>PMID:21129200</ref> [[http://www.uniprot.org/uniprot/BP07_BPT4 BP07_BPT4]] Baseplate protein that is part of the baseplate wedge. Involved in the tail assembly.<ref>PMID:2254933</ref> <ref>PMID:21129200</ref> [[http://www.uniprot.org/uniprot/BP27_BPT4 BP27_BPT4]] Baseplate protein that is part of the baseplate hub. Involved in the tail assembly.<ref>PMID:12837775</ref> <ref>PMID:21129200</ref> [[http://www.uniprot.org/uniprot/TUBE_BPT4 TUBE_BPT4]] Structural component of the bacteriophage tail which consists of a contractile sheath, a tube and a baseplate. The central cylindrical segment of the tail consists of a rigid tube, composed of multiple copies of gp19, surrounded by the outer contractile sheath assembled from gp18 subunits. During infection, contraction of the sheath drives the central tube through the host outer membrane, creating a channel for DNA ejection from the capsid into the host cell.<ref>PMID:14625682</ref> [[http://www.uniprot.org/uniprot/BP06_BPT4 BP06_BPT4]] Baseplate protein that is part of the baseplate wedge (PubMed:15315755). Involved in the tail assembly.<ref>PMID:15315755</ref> <ref>PMID:21129200</ref> [[http://www.uniprot.org/uniprot/BP09_BPT4 BP09_BPT4]] Baseplate protein that connects the long tail fibers to the baseplate and probably triggers the tail contraction after virus attachment to a host cell (PubMed:10545330). Involved in the tail assembly (PubMed:21129200).<ref>PMID:10545330</ref> <ref>PMID:21129200</ref> [[http://www.uniprot.org/uniprot/NEEDL_BPT4 NEEDL_BPT4]] Tail-associated lysozyme of the baseplate hub that is essential for localized hydrolysis of bacterial cell wall necessary for viral DNA injection. The needle-like gp5 protein punctures the outer cell membrane and then digests the peptidoglycan cell wall in the periplasmic space. Involved in the tail assembly.<ref>PMID:12837775</ref> <ref>PMID:21129200</ref> [[http://www.uniprot.org/uniprot/BP48_BPT4 BP48_BPT4]] Baseplate protein that is part of the baseplate-tail tube junction. Morphogenesis of the baseplate is completed by association of gp48 and gp54, allowing the initiation of the tail-tube polymerization. Involved in the tail assembly.<ref>PMID:3363870</ref> <ref>PMID:21129200</ref> [[http://www.uniprot.org/uniprot/BP10_BPT4 BP10_BPT4]] Baseplate protein that is part of the baseplate wedge and that connects the short tail fibers to the baseplate (PubMed:16554069). During infection, the baseplate undergoes a conformational change from a dome-shaped to a star-shaped structure. At this point, gp10 rotates and acts as a lever that unfolds the short tail fibers, which then interact with host cell surface receptors. Involved in the tail assembly.<ref>PMID:16554069</ref> <ref>PMID:21129200</ref> |
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== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Revision as of 04:07, 30 August 2017
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Cryo-electron microscopy structure of the hexagonal pre-attachment T4 baseplate-tail tube complex
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