1wfa
From Proteopedia
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|PDB= 1wfa |SIZE=350|CAPTION= <scene name='initialview01'>1wfa</scene>, resolution 1.7Å | |PDB= 1wfa |SIZE=350|CAPTION= <scene name='initialview01'>1wfa</scene>, resolution 1.7Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=NH2:AMINO GROUP'>NH2</scene> | + | |LIGAND= <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wfa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wfa OCA], [http://www.ebi.ac.uk/pdbsum/1wfa PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1wfa RCSB]</span> | ||
}} | }} | ||
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[[Category: Sicheri, F.]] | [[Category: Sicheri, F.]] | ||
[[Category: Yang, D S.C.]] | [[Category: Yang, D S.C.]] | ||
| - | [[Category: NH2]] | ||
[[Category: ice binding protein]] | [[Category: ice binding protein]] | ||
[[Category: thermal hysteresis protein]] | [[Category: thermal hysteresis protein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:35:28 2008'' |
Revision as of 21:35, 30 March 2008
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| , resolution 1.7Å | |||||||
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| Ligands: | |||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
WINTER FLOUNDER ANTIFREEZE PROTEIN ISOFORM HPLC6 AT 4 DEGREES C
Overview
Antifreeze proteins provide fish with protection against the freezing effect of polar environments by binding to ice surfaces and inhibiting growth of ice crystals. We present the X-ray crystal structure at 1.5 A resolution of a lone alpha-helical antifreeze protein from winter flounder, which provides a detailed look at its ice-binding features. These consist of four repeated ice-binding motifs, the side chains of which are inherently rigid or restrained by pair-wise side-chain interactions to form a flat binding surface. Elaborate amino- and carboxy-terminal cap structures are also present, which explain the protein's rich alpha-helical content in solution. We propose an ice-binding model that accounts for the binding specificity of the antifreeze protein along the <0112> axes of the (2021) ice planes.
About this Structure
1WFA is a Single protein structure of sequence from Pseudopleuronectes americanus. Full crystallographic information is available from OCA.
Reference
Ice-binding structure and mechanism of an antifreeze protein from winter flounder., Sicheri F, Yang DS, Nature. 1995 Jun 1;375(6530):427-31. PMID:7760940
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