Plasmid segregation protein ParM
From Proteopedia
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| - | <StructureSection load='4a61' size='400' side='right' caption='plasmid segregation protein ParM complex with AMPPNP (stick model) and Mg+2 ion (green) (PDB code [[4a61]])' scene=''> | + | <StructureSection load='4a61' size='400' side='right' caption='plasmid segregation protein ParM complex with AMPPNP (stick model) and Mg+2 ion (green) (PDB code [[4a61]])' scene='' pspeed='8'> |
== Function == | == Function == | ||
'''Plasmid segregation protein''' (ParM) is required for plasmid partition and accurate segregation of low-copy-number plasmid R1<ref>PMID:20844556</ref>. | '''Plasmid segregation protein''' (ParM) is required for plasmid partition and accurate segregation of low-copy-number plasmid R1<ref>PMID:20844556</ref>. | ||
== Structural highlights == | == Structural highlights == | ||
| - | ParM polymerizes into double helical protofilaments with repeats similar to F-actin. | + | ParM polymerizes into double helical protofilaments with repeats similar to F-actin. <scene name='71/715423/Cv/2'>AMPPNP binding site</scene>. |
| + | *<scene name='71/715423/Cv/3'>Mg coordination site</scene>. Water molecules shown as red spheres. | ||
Revision as of 11:26, 3 September 2017
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3D structures of plasmid segregation protein ParM
Updated on 03-September-2017
1mwk – ParM – Escherichias coli
1mwm – ParM + ADP
2zgy – ParM + GDP
2zgz – ParM + GMPPNP
4a61 – ParM + AMPPNP
5aey – ParM + AMPPNP - CryoEM
4a62 – ParM + ParR C terminus
2qu4, 2ghc, 3iku, 3iky, 4a6j, 5ai7 – ParM – CryoEM
References
- ↑ Salje J, Gayathri P, Lowe J. The ParMRC system: molecular mechanisms of plasmid segregation by actin-like filaments. Nat Rev Microbiol. 2010 Oct;8(10):683-92. doi: 10.1038/nrmicro2425. PMID:20844556 doi:http://dx.doi.org/10.1038/nrmicro2425
