5u7m
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer bound to small molecule HIV-1 entry inhibitor BMS-378806 in Complex with Human Antibodies PGT122 and 35O22 at 3.8 A.== | |
| - | + | <StructureSection load='5u7m' size='340' side='right' caption='[[5u7m]], [[Resolution|resolution]] 3.02Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5u7m]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U7M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5U7M FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=83G:1-[(2R)-4-(benzenecarbonyl)-2-methylpiperazin-1-yl]-2-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)ethane-1,2-dione'>83G</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[ | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5u7o|5u7o]]</td></tr> |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5u7m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u7m OCA], [http://pdbe.org/5u7m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5u7m RCSB], [http://www.ebi.ac.uk/pdbsum/5u7m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5u7m ProSAT]</span></td></tr> |
| - | [[Category: Kwong, P | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/Q2N0S5_9HIV1 Q2N0S5_9HIV1]] The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface.[RuleBase:RU004292][SAAS:SAAS00139820] The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves.[SAAS:SAAS00140087] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Kwong, P D]] | ||
| + | [[Category: Lai, Y T]] | ||
[[Category: Pancera, M]] | [[Category: Pancera, M]] | ||
| + | [[Category: Hiv-1 entry]] | ||
| + | [[Category: Inhibitor]] | ||
| + | [[Category: Small molecule]] | ||
| + | [[Category: Viral protein-immune system complex]] | ||
Revision as of 14:56, 5 September 2017
Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer bound to small molecule HIV-1 entry inhibitor BMS-378806 in Complex with Human Antibodies PGT122 and 35O22 at 3.8 A.
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