5p9a
From Proteopedia
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m (Protected "5p9a" [edit=sysop:move=sysop]) |
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- | '''Unreleased structure''' | ||
- | + | ==rat catechol O-methyltransferase in complex with N-[2-[2-(6-aminopurin-9-yl)ethoxy]ethyl]-5-(4-fluorophenyl)-2,3-dihydroxybenzamide at 1.91A== | |
- | + | <StructureSection load='5p9a' size='340' side='right' caption='[[5p9a]], [[Resolution|resolution]] 1.91Å' scene=''> | |
- | + | == Structural highlights == | |
- | + | <table><tr><td colspan='2'>[[5p9a]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5P9A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5P9A FirstGlance]. <br> | |
- | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=77N:N-[2-[2-(6-aminopurin-9-yl)ethoxy]ethyl]-5-(4-fluorophenyl)-2,3-dihydroxybenzamide'>77N</scene>, <scene name='pdbligand=D1D:(4S,5S)-1,2-DITHIANE-4,5-DIOL'>D1D</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |
- | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Catechol_O-methyltransferase Catechol O-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.6 2.1.1.6] </span></td></tr> |
+ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5p9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5p9a OCA], [http://pdbe.org/5p9a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5p9a RCSB], [http://www.ebi.ac.uk/pdbsum/5p9a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5p9a ProSAT]</span></td></tr> | ||
+ | </table> | ||
+ | == Function == | ||
+ | [[http://www.uniprot.org/uniprot/COMT_RAT COMT_RAT]] Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol. | ||
+ | __TOC__ | ||
+ | </StructureSection> | ||
+ | [[Category: Catechol O-methyltransferase]] | ||
+ | [[Category: Ehler, A]] | ||
+ | [[Category: Lerner, C]] | ||
+ | [[Category: Rudolph, M G]] | ||
+ | [[Category: Methyltransferase]] | ||
+ | [[Category: Neurotransmitter degradation]] | ||
+ | [[Category: Transferase]] |
Revision as of 15:01, 5 September 2017
rat catechol O-methyltransferase in complex with N-[2-[2-(6-aminopurin-9-yl)ethoxy]ethyl]-5-(4-fluorophenyl)-2,3-dihydroxybenzamide at 1.91A
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