5i7d

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'''Unreleased structure'''
 
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The entry 5i7d is ON HOLD until Paper Publication
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==Crystal Structure of srGAP2 F-BARx WT Form-2==
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<StructureSection load='5i7d' size='340' side='right' caption='[[5i7d]], [[Resolution|resolution]] 3.95&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5i7d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I7D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5I7D FirstGlance]. <br>
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Description:
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5i7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i7d OCA], [http://pdbe.org/5i7d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i7d RCSB], [http://www.ebi.ac.uk/pdbsum/5i7d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5i7d ProSAT]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/SRGP2_HUMAN SRGP2_HUMAN]] A chromosomal aberration disrupting SRGAP2 has been found in a patient with early infantile epileptic encephalopathy. Balanced translocation t(1;9)(q32;q13).
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== Function ==
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[[http://www.uniprot.org/uniprot/SRGP2_HUMAN SRGP2_HUMAN]] RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral cortex. Its interaction and inhibition by SRGAP2C reduces the rate of spine maturation, alters dendritic spine morphology and density and indirectly increases neuronal migration. It may have implications for cognition, learning and memory. In non-neuronal cells, it may also play a role in cell migration by regulating the formation of lamellipodia and filopodia.<ref>PMID:20810653</ref> <ref>PMID:21148482</ref> <ref>PMID:22559944</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Guez-Haddad, J]]
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[[Category: Isupov, M N]]
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[[Category: Opatowsky, Y]]
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[[Category: Sporny, M]]
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[[Category: F-bar]]
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[[Category: Fx]]
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[[Category: Signaling protein]]
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[[Category: Srgap2]]

Revision as of 15:06, 5 September 2017

Crystal Structure of srGAP2 F-BARx WT Form-2

5i7d, resolution 3.95Å

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