5x83

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m (Protected "5x83" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5x83 is ON HOLD
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==Structure of DCC FN456 domains==
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<StructureSection load='5x83' size='340' side='right' caption='[[5x83]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5x83]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X83 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5X83 FirstGlance]. <br>
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Description:
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5x83 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x83 OCA], [http://pdbe.org/5x83 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5x83 RCSB], [http://www.ebi.ac.uk/pdbsum/5x83 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5x83 ProSAT]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/DCC_HUMAN DCC_HUMAN]] Defects in DCC are the cause of mirror movements type 1 (MRMV1) [MIM:[http://omim.org/entry/157600 157600]]. A disorder characterized by contralateral involuntary movements that mirror voluntary ones. While mirror movements are occasionally found in young children, persistence beyond the age of 10 is abnormal. Mirror movements occur more commonly in the upper extremities.<ref>PMID:20431009</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/DCC_HUMAN DCC_HUMAN]] Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.<ref>PMID:8861902</ref> <ref>PMID:8187090</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Finci, F I]]
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[[Category: Wang, J]]
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[[Category: Xiao, J]]
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[[Category: Axon guidance]]
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[[Category: Dcc]]
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[[Category: Netrin-1]]
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[[Category: Signaling protein]]

Revision as of 03:47, 6 September 2017

Structure of DCC FN456 domains

5x83, resolution 3.00Å

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