Phosphoribosyltransferase

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Line 53: Line 53:
**[[4hib]], [[4hkp]] - hOPRT + inhibitor<br />
**[[4hib]], [[4hkp]] - hOPRT + inhibitor<br />
**[[4rv4]] - BaOPRT + PRPP<BR />
**[[4rv4]] - BaOPRT + PRPP<BR />
 +
**[[4wml]], [[4wn3] - yOPRT + PRPP<BR />
**[[1opr]], [[1lh0]] - StOPRT + orotate + PRPP<BR />
**[[1opr]], [[1lh0]] - StOPRT + orotate + PRPP<BR />
**[[2ps1]] - yOPRT + orotate + PRPP<BR />
**[[2ps1]] - yOPRT + orotate + PRPP<BR />
 +
**[[5hki]] – MtOPRT + Fe-citrate – ''Mycobacterium tuberculosis'' <br />
 +
**[[5hkf]] - MtOPRT + PRPP<BR />
 +
**[[5hkl]] - MtOPRT (mutant) + Pi<BR />
*'''Hypoxanthine-guanine phosphoribosyltransferase'''
*'''Hypoxanthine-guanine phosphoribosyltransferase'''
Line 143: Line 147:
*'''Uracil phosphoribosyltransferase'''
*'''Uracil phosphoribosyltransferase'''
-
**[[1w30]] - MtUPRT <br />
+
**[[1w30]], [[5e38]] - MtUPRT <br />
**[[1bd3]] - TgUPRT (mutant) <br />
**[[1bd3]] - TgUPRT (mutant) <br />
**[[1v9s]] - TtUPRT <br />
**[[1v9s]] - TtUPRT <br />
Line 168: Line 172:
**[[4lza]] – APRT – ''Thermoanaerobacter pseudethanolicus''<br />
**[[4lza]] – APRT – ''Thermoanaerobacter pseudethanolicus''<br />
**[[4m0k]] – APRT – ''Rhodothermus marinus''<br />
**[[4m0k]] – APRT – ''Rhodothermus marinus''<br />
-
**[[4mb6]] – APRT – ''Yersinia pseudotuberculosis''<br />
+
**[[4mb6]] – YpAPRT – ''Yersinia pseudotuberculosis''<br />
**[[4trb]] – SsAPRT <br />
**[[4trb]] – SsAPRT <br />
Line 178: Line 182:
**[[1qb8]] - LdAPRT + AMP<br />
**[[1qb8]] - LdAPRT + AMP<br />
**[[1ore]], [[1zn8]], [[1zn9]] - hAPRT + AMP<br />
**[[1ore]], [[1zn8]], [[1zn9]] - hAPRT + AMP<br />
 +
**[[4x44]], [[4x45]] - hAPRT (mutant) + AMP - human<br />
 +
**[[5b6h]] - YpAPRT + AMP <br />
**[[1mzv]] - LtAPRT + AMP<br />
**[[1mzv]] - LtAPRT + AMP<br />
**[[4ts7]] - SsAPRT + ADP<br />
**[[4ts7]] - SsAPRT + ADP<br />
Line 186: Line 192:
*'''Nicotinate mononucleotide:5, 6-dimethylbenzimidazole phosphoribosyltransferase'''
*'''Nicotinate mononucleotide:5, 6-dimethylbenzimidazole phosphoribosyltransferase'''
-
**[[1l4b]] – SeNN:DBI PRT – ''Salmonella enterica''<br />
+
**[[1l4b]] – StNN:DBI PRT <br />
-
**[[4kqh]] - SeNN:DBI PRT (mutant)<br />
+
**[[4kqh]] - StNN:DBI PRT (mutant)<br />
**[[1wx1]] – TtNN:DBI PRT <br />
**[[1wx1]] – TtNN:DBI PRT <br />
**[[3u4g]] – PhNN:DBI PRT
**[[3u4g]] – PhNN:DBI PRT
Line 193: Line 199:
*Nicotinate mononucleotide:5, 6-dimethylbenzimidazole phosphoribosyltransferase complex
*Nicotinate mononucleotide:5, 6-dimethylbenzimidazole phosphoribosyltransferase complex
-
**[[1jh8]], [[4kqf]] – SeNN:DBI PRT + adenine<br />
+
**[[1jh8]], [[4kqf]] – StNN:DBI PRT + adenine<br />
-
**[[1l4e]], [[1l4f]], [[1l4g]], [[1l4h]], [[1l4k]], [[1l4l]], [[1l4m]], [[1l4n]], [[1l5f]], [[1l5k]], [[1l5l]], [[1l5m]], [[1l5n]], [[1l5o]] - SeNN:DBI PRT + product-aldimine complex<br />
+
**[[1l4e]], [[1l4f]], [[1l4g]], [[1l4h]], [[1l4k]], [[1l4l]], [[1l4m]], [[1l4n]], [[1l5f]], [[1l5k]], [[1l5l]], [[1l5m]], [[1l5n]], [[1l5o]] - StNN:DBI PRT + product-aldimine complex<br />
-
**[[1jha]] – SeNN:DBI PRT + AMP + nicotinate<br />
+
**[[1jha]] – StNN:DBI PRT + AMP + nicotinate<br />
-
**[[4kqi]] - SeNN:DBI PRT (mutant) + nicotinate + α-ribazole phosphate<br />
+
**[[4kqi]], [[1dov]] - StNN:DBI PRT (mutant) + nicotinate + α-ribazole phosphate<br />
-
**[[1jhm]] – SeNN:DBI PRT + benzimidazole<br />
+
**[[1jhm]] – StNN:DBI PRT + benzimidazole<br />
-
**[[1jho]] – SeNN:DBI PRT + NaMN + benzimidazole<br />
+
**[[1jho]] – StNN:DBI PRT + NaMN + benzimidazole<br />
-
**[[1jhp]] – SeNN:DBI PRT + benzimidazole derivative<br />
+
**[[1jhp]], [[1d0s]] – StNN:DBI PRT + benzimidazole derivative<br />
-
**[[1jhq]] - SeNN:DBI PRT + NaMN + benzimidazole derivative<br />
+
**[[1jhq]] - StNN:DBI PRT + NaMN + benzimidazole derivative<br />
-
**[[1jhr]] - SeNN:DBI PRT + NaMN + hydroxypurine<br />
+
**[[1jhr]] - StNN:DBI PRT + NaMN + hydroxypurine<br />
-
**[[1jhu]] - SeNN:DBI PRT + cresol<br />
+
**[[1jhu]] - StNN:DBI PRT + cresol<br />
-
**[[4kqk]] - SeNN:DBI PRT (mutant) + cresol<br />
+
**[[4kqk]] - StNN:DBI PRT (mutant) + cresol<br />
-
**[[1jhv]] - SeNN:DBI PRT + nicotinate + cresol<br />
+
**[[1jhv]] - StNN:DBI PRT + nicotinate + cresol<br />
-
**[[1jhx]] - SeNN:DBI PRT + phenol<br />
+
**[[1jhx]] - StNN:DBI PRT + phenol<br />
-
**[[1jhy]] - SeNN:DBI PRT + phenol + nicotinate<br />
+
**[[1jhy]] - StNN:DBI PRT + phenol + nicotinate<br />
-
**[[4kqj]] - SeNN:DBI PRT (mutant) + NaMN + cresol<br />
+
**[[4kqj]] - StNN:DBI PRT (mutant) + NaMN + cresol<br />
-
**[[4kqg]] - SeNN:DBI PRT (mutant) + cobamide<br />
+
**[[4kqg]] - StNN:DBI PRT (mutant) + cobamide<br />
*'''Anthranilate phosphoribosyltransferase'''
*'''Anthranilate phosphoribosyltransferase'''
Line 216: Line 222:
**[[1v8g]], [[2elc]] - TtANPRT <br />
**[[1v8g]], [[2elc]] - TtANPRT <br />
**[[1vqu]] - ANPRT – Nostoc<br />
**[[1vqu]] - ANPRT – Nostoc<br />
-
**[[3qr9]] – MtANPRT<br />
+
**[[3qr9]], [[5c2l]] – MtANPRT<br />
 +
**[[4x5a]] - MtANPRT (mutant) <BR />
**[[4hkm]] - ANPRT – ''Xanthomonas campestris''<br />
**[[4hkm]] - ANPRT – ''Xanthomonas campestris''<br />
-
**[[4gtn]] – ANPRT – ''Acinetobacter''<br />
+
**[[4gtn]] – AcANPRT – ''Acinetobacter''<br />
-
*Anthranilate phosphoribosyltransferase complex
+
*Anthranilate phosphoribosyltransferase complex containing anthranilate
 +
 
 +
**[[4owm]], [[4own]], [[4owo]], [[4owq]], [[4ows]], [[4owu]], [[4n5v]], 4n93]] - MtANPRT + PRPP + anthranilate derivative<BR />
 +
**[[4ij1]], [[4m0r]], [[4owv]], [[4n8q]] - MtANPRT + anthranilate derivative <br />
 +
**[[4x5d]] - MtANPRT (mutant) + anthranilate<BR />
 +
**[[4x5e]] - MtANPRT (mutant) + anthranilate + POP<BR />
 +
**[[1zyk]] - SsANPRT + anthranilate + PRPP<BR />
 +
**[[4giu]], [[4gkm]]- PfANPRT + anthranilate derivative + PRPP<br />
 +
**[[4yi7]] - AcMtANPRT + anthranilate<BR />
 +
 
 +
*Anthranilate phosphoribosyltransferase other complexes
**[[1kgz]] - PcANPRT + PRPP<BR />
**[[1kgz]] - PcANPRT + PRPP<BR />
-
**[[1zvw]] - MtANPRT + PRPP<BR />
+
**[[1zvw]], [[5byt]], [[5c1r]], [[5c7s]] - MtANPRT + PRPP<BR />
-
**[[4n5v]], [[4n93]] - MtANPRT + PRPP + aminofluorobenzoate<BR />
+
**[[4x58]], [[4x59]], [[4x5b]] - MtANPRT (mutant) + PRPP<BR />
-
**[[4owm]], [[4own]], [[4owo]], [[4owq]], [[4ows]], [[4owu]] - MtANPRT + PRPP + anthranilate derivative<BR />
+
**[[4x5c]] - MtANPRT (mutant) + PRPP + POP<BR />
-
**[[4n8q]] - MtANPRT + aminofluorobenzoate<BR />
+
-
**[[4owv]] - MtANPRT + aminobenzoate<BR />
+
-
**[[4ij1]], [[4m0r]] - MtANPRT + anthranilate derivative <br />
+
**[[1zxy]] - SsANPRT + PRPP<BR />
**[[1zxy]] - SsANPRT + PRPP<BR />
**[[3gbr]] - SsANPRT (mutant) + PRPP<BR />
**[[3gbr]] - SsANPRT (mutant) + PRPP<BR />
-
**[[1gxb]] - SsANPRT + pyrophosphate<br />
+
**[[1gxb]] - SsANPRT + POP<br />
**[[2gvq]] - SsANPRT + anthranilate<br />
**[[2gvq]] - SsANPRT + anthranilate<br />
-
**[[3qqs]], [[3qs8]], [[3qsa]], [[3r6c]], [[3r88]], [[3twp]], [[3uu1]] - MtANPRT + inhibitor + PRPP<BR />
+
**[[4ztv]], [[5bne]], [[5bo2]], [[5bo3]] - MtANPRT + inhibitor <BR />
-
**[[1zyk]] - SsANPRT + anthranilate + PRPP<BR />
+
**[[3qqs]], [[3qs8]], [[3qsa]], [[3r6c]], [[3r88]], [[3twp]], [[3uu1]], [[4zof]], [[4zoj]], [[4zok]] - MtANPRT + inhibitor + PRPP<BR />
-
**[[4giu]], [[4gkm]]- PfANPRT + anthranilate derivative + PRPP<br />
+
*'''ATP phosphoribosyltransferase''' See [[ATP Phosphoribosyl Transferase]]
*'''ATP phosphoribosyltransferase''' See [[ATP Phosphoribosyl Transferase]]
Line 248: Line 261:
**[[2im5]] - NIPRT – ''Porphyromonas gingivalis''<br />
**[[2im5]] - NIPRT – ''Porphyromonas gingivalis''<br />
**[[3os4]] - NIPRT – ''Yersinia pestis''<br />
**[[3os4]] - NIPRT – ''Yersinia pestis''<br />
-
**[[4hl7]] - VcNIPRT
+
**[[4hl7]] - VcNIPRT <br />
 +
**[[4yub]] - hNIPRT <br />
*Nicotinate phosphoribosyltransferase complex
*Nicotinate phosphoribosyltransferase complex
Line 273: Line 287:
**[[2e5d]] - hNMPRT + nicotinamide<br />
**[[2e5d]] - hNMPRT + nicotinamide<br />
**[[3dgr]] - hNMPRT + ADP analog<br />
**[[3dgr]] - hNMPRT + ADP analog<br />
-
**[[4jnm]], [[4jr5]], [[4kfn]], [[4kfo]], [[4kfp]], [[4lts]], [[4lv9]], [[4lva]], [[4lvb]], [[4lvd]], [[4lvf]], [[4lvg]], [[4lww]], [[4m6p]], [[4m6q]], [[4n9b]], [[4n9c]], [[4n9d]], [[4n9e]], [[4l4l]], [[4l4m]], [[4o0z]], [[4o10]], [[4o12]], [[4o13]], [[4o14]], [[4o15]], [[4o16]], [[4o17]], [[4o18]], [[4o19]], [[4o1a]], [[4o1b]], [[4o1c]], [[4o1d]], [[4wq6]] - hNMPRT + inhibitor<br />
+
**[[4jnm]], [[4jr5]], [[4kfn]], [[4kfo]], [[4kfp]], [[4lts]], [[4lv9]], [[4lva]], [[4lvb]], [[4lvd]], [[4lvf]], [[4lvg]], [[4lww]], [[4m6p]], [[4m6q]], [[4n9b]], [[4n9c]], [[4n9d]], [[4n9e]], [[4l4l]], [[4l4m]], [[4o0z]], [[4o10]], [[4o12]], [[4o13]], [[4o14]], [[4o15]], [[4o16]], [[4o17]], [[4o18]], [[4o19]], [[4o1a]], [[4o1b]], [[4o1c]], [[4o1d]], [[4wq6]], [[4o28]], [[5kit]], [[5u2m]], [[5u2n]], [[5upe]], [[5upf]] - hNMPRT + inhibitor<br />
**[[3dhd]], [[3dhf]] - hNMPRT + pyrophosphate + NMN<BR />
**[[3dhd]], [[3dhf]] - hNMPRT + pyrophosphate + NMN<BR />
**[[3dkj]], [[3dkl]] - hNMPRT + benzamide + PRPP<BR />
**[[3dkj]], [[3dkl]] - hNMPRT + benzamide + PRPP<BR />

Revision as of 08:10, 6 September 2017

Yeast orotate phosphoribosyltransferase dimer complex with orotate and PRPP (PDB entry 2ps1)

Drag the structure with the mouse to rotate

3D structures of phosphoribosyltransferase

Updated on 06-September-2017

References

  1. ↑ Sculley DG, Dawson PA, Emmerson BT, Gordon RB. A review of the molecular basis of hypoxanthine-guanine phosphoribosyltransferase (HPRT) deficiency. Hum Genet. 1992 Nov;90(3):195-207. PMID:1487231
  2. ↑ Gonzalez-Segura L, Witte JF, McClard RW, Hurley TD. Ternary complex formation and induced asymmetry in orotate phosphoribosyltransferase. Biochemistry. 2007 Dec 11;46(49):14075-86. Epub 2007 Nov 20. PMID:18020427 doi:10.1021/bi701023z
  3. ↑ Foster AC, Whetsell WO Jr, Bird ED, Schwarcz R. Quinolinic acid phosphoribosyltransferase in human and rat brain: activity in Huntington's disease and in quinolinate-lesioned rat striatum. Brain Res. 1985 Jun 17;336(2):207-14. PMID:3159462
  4. ↑ Carter D, Donald RG, Roos D, Ullman B. Expression, purification, and characterization of uracil phosphoribosyltransferase from Toxoplasma gondii. Mol Biochem Parasitol. 1997 Aug;87(2):137-44. PMID:9247925
  5. ↑ . PMID:121011881
  6. ↑ Castell A, Short FL, Evans GL, Cookson TV, Bulloch EM, Joseph DD, Lee CE, Parker EJ, Baker EN, Lott JS. Substrate capture mechanism of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase provides a mode for inhibition. Biochemistry. 2013 Jan 30. PMID:23363292 doi:http://dx.doi.org/10.1021/bi301387m
  7. ↑ Pedreno S, Pisco JP, Larrouy-Maumus G, Kelly G, de Carvalho LP. Mechanism of feedback allosteric inhibition of ATP phosphoribosyltransferase. Biochemistry. 2012 Oct 9;51(40):8027-38. doi: 10.1021/bi300808b. Epub 2012 Sep, 27. PMID:22989207 doi:http://dx.doi.org/10.1021/bi300808b
  8. ↑ Galassi L, Di Stefano M, Brunetti L, Orsomando G, Amici A, Ruggieri S, Magni G. Characterization of human nicotinate phosphoribosyltransferase: Kinetic studies, structure prediction and functional analysis by site-directed mutagenesis. Biochimie. 2012 Feb;94(2):300-9. doi: 10.1016/j.biochi.2011.06.033. Epub 2011 Jul, 3. PMID:21742010 doi:http://dx.doi.org/10.1016/j.biochi.2011.06.033
  9. ↑ Imai S. Nicotinamide phosphoribosyltransferase (Nampt): a link between NAD biology, metabolism, and diseases. Curr Pharm Des. 2009;15(1):20-8. PMID:19149599
  10. ↑ Tohyama J, Nanba E, Ohno K. Hypoxanthine-guanine phosphoribosyltransferase (HPRT) deficiency: identification of point mutations in Japanese patients with Lesch-Nyhan syndrome and hereditary gout and their permanent expression in an HPRT-deficient mouse cell line. Hum Genet. 1994 Feb;93(2):175-81. PMID:8112742
  11. ↑ Montecucco F, Cea M, Cagnetta A, Damonte P, Nahimana A, Ballestrero A, Del Rio A, Bruzzone S, Nencioni A. Nicotinamide phosphoribosyltransferase as a target in inflammation- related disorders. Curr Top Med Chem. 2013;13(23):2930-8. PMID:24171767
  12. ↑ Gonzalez-Segura L, Witte JF, McClard RW, Hurley TD. Ternary complex formation and induced asymmetry in orotate phosphoribosyltransferase. Biochemistry. 2007 Dec 11;46(49):14075-86. Epub 2007 Nov 20. PMID:18020427 doi:10.1021/bi701023z

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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