Phosphoserine phosphatase
From Proteopedia
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<StructureSection load='' size='450' side='right' scene='48/488517/Cv/1' caption='Human phosphoserine phosphatase dimer complex with serine and phosphate [[1l8o]]'> | <StructureSection load='' size='450' side='right' scene='48/488517/Cv/1' caption='Human phosphoserine phosphatase dimer complex with serine and phosphate [[1l8o]]'> | ||
== Function == | == Function == | ||
| - | '''Phosphoserine phosphatase''' (PSP) catalyzes the dephosphorylation of phosphoserine to produce serine and phosphate. This is the last reaction in serine biosynthesis. PSP is part of the glycine, serine and threonine metabolism<ref>PMID:13610904</ref>. Mg+2 ion is a cofactor of PSP. | + | '''Phosphoserine phosphatase''' (PSP) catalyzes the dephosphorylation of phosphoserine to produce serine and phosphate. This is the last reaction in serine biosynthesis. PSP is part of the glycine, serine and threonine metabolism<ref>PMID:13610904</ref>. Mg<sup>+2</sup> ion is a cofactor of PSP. |
== Disease == | == Disease == | ||
Revision as of 06:22, 7 September 2017
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3D structures of phosphoserine phosphatase
Updated on 07-September-2017
References
- ↑ NEUHAUS FC, BYRNE WL. Metabolism of phosphoserine. II. Purification and properties of O-phosphoserine phosphatase. J Biol Chem. 1959 Jan;234(1):113-21. PMID:13610904
- ↑ Jaeken J, Detheux M, Fryns JP, Collet JF, Alliet P, Van Schaftingen E. Phosphoserine phosphatase deficiency in a patient with Williams syndrome. J Med Genet. 1997 Jul;34(7):594-6. PMID:9222972
- ↑ Kim HY, Heo YS, Kim JH, Park MH, Moon J, Kim E, Kwon D, Yoon J, Shin D, Jeong EJ, Park SY, Lee TG, Jeon YH, Ro S, Cho JM, Hwang KY. Molecular basis for the local conformational rearrangement of human phosphoserine phosphatase. J Biol Chem. 2002 Nov 29;277(48):46651-8. Epub 2002 Sep 3. PMID:12213811 doi:10.1074/jbc.M204866200
