Plectin
From Proteopedia
(Difference between revisions)
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<Structure load='1sh6' size='400' caption='Mouse plectin actin-binding domain [[1sh6]]' scene= '> | <Structure load='1sh6' size='400' caption='Mouse plectin actin-binding domain [[1sh6]]' scene= '> | ||
== Function == | == Function == | ||
| - | '''Plectin''', a universal and functionally versatile cytolinker protein, can be divided in three main sections; a central coiled-coil rod domain (residues 1492-1530), N and C-terminal globular region and exhibits a dumbbell like structure <ref>PMID:3430617</ref>. C-terminal region is composed of 6 homologous repeating domains (repeat#6 contains residues 4403-4606), and this region has a role in binding to intermediate filaments such as vimentin and cytokeratin<ref>PMID:24810881</ref>, <ref>PMID:24940650</ref>. N-terminal globular region contains actin binding domain (ABD) (residues 175-400) comprising of two calponin homology (CH) domains, plakin domain (residues | + | '''Plectin''', a universal and functionally versatile cytolinker protein, can be divided in three main sections; a central coiled-coil rod domain (residues 1492-1530), N and C-terminal globular region and exhibits a dumbbell like structure <ref>PMID:3430617</ref>. C-terminal region is composed of 6 homologous repeating domains (repeat#6 contains residues 4403-4606), and this region has a role in binding to intermediate filaments such as vimentin and cytokeratin<ref>PMID:24810881</ref>, <ref>PMID:24940650</ref>. N-terminal globular region contains actin binding domain (ABD) (residues 175-400) comprising of two calponin homology (CH) domains, plakin domain (residues 300-1372) and N-terminal arm, which varies among isoforms. |
For more details see [[Group:MUZIC:Plectin]]. | For more details see [[Group:MUZIC:Plectin]]. | ||
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[[1mb8]], [[4q59]] – hPCN actin-binding domain – human<br /> | [[1mb8]], [[4q59]] – hPCN actin-binding domain – human<br /> | ||
[[1sh5]], [[1sh6]] - PCN actin-binding domain – mouse<br /> | [[1sh5]], [[1sh6]] - PCN actin-binding domain – mouse<br /> | ||
| - | + | [[3pe0]] - hPCN plakin domain residues 747-918<br /> | |
| - | [[2odu]], [[2odv]] – hPCN plakin domain (mutant)<br /> | + | [[2odu]], [[2odv]] – hPCN plakin domain residues 300-530 (mutant)<br /> |
| + | [[3pdy]] – hPCN plakin domain repeats 3-4<br /> | ||
| + | [[5j1g]] – hPCN plakin domain repeats 7-8<br /> | ||
| + | [[5j1f]], [[5j1h]] – hPCN plakin domain repeats 5-6<br /> | ||
| + | [[5j1i]] – hPCN plakin domain repeats 7-9<br /> | ||
[[4gdo]] – hPCN rod domain<br /> | [[4gdo]] – hPCN rod domain<br /> | ||
[[3f7p]], [[4q58]] - hPCN actin-binding domain + integrin β4 residues 1126-1370<br /> | [[3f7p]], [[4q58]] - hPCN actin-binding domain + integrin β4 residues 1126-1370<br /> | ||
[[4q57]] - hPCN actin-binding domain + calmodulin N terminal<br /> | [[4q57]] - hPCN actin-binding domain + calmodulin N terminal<br /> | ||
| + | [[2n03]] – hPCN C-terminal repeat domain 6 - NMR<br /> | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 10:34, 11 September 2017
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