Plexin

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*Plexin A
*Plexin A
 +
**[[5l56]], [[5l59]], [[5l5c]] – mPLX-A1 extracellular domain segment 1-10 - mouse<br />
 +
**[[5l7n]] – mPLX-A1 extracellular domain segment 7-10<br />
 +
**[[3ryt]] - mPLX-A1 intracellular domain + Ras-related C3 botulinum toxin substrate<br />
**[[3al8]], [[3oky]] – mPLX-A2 + semaphorin-6A – mouse<br />
**[[3al8]], [[3oky]] – mPLX-A2 + semaphorin-6A – mouse<br />
**[[4gza]] - mPLX-A2 + semaphorin-3A + neuropilin-1<br />
**[[4gza]] - mPLX-A2 + semaphorin-3A + neuropilin-1<br />
-
**[[3al9]], [[3okt]] – mPLX-A2 extracellular domain<br />
+
**[[3al9]] – mPLX-A2 SEMA+PSI domain<br />
-
**[[3ig3]] - mPLX-A3 intracellular domain<br />
+
**[[3okt]] - mPLX-A2 extracellular domain segment 1-4<br />
-
**[[3ryt]] - mPLX-A1 intracellular domain + Ras-related C3 botulinum toxin substrate<br />
+
**[[5l5g]] – mPLX-A2 extracellular domain segment 1-8<br />
 +
**[[5l74]] – mPLX-A2 extracellular domain segment 4-5<br />
**[[3q3j]] - hPLX-A2 binding domain + Rho-related GTP-binding protein Rho6 – human<br />
**[[3q3j]] - hPLX-A2 binding domain + Rho-related GTP-binding protein Rho6 – human<br />
 +
**[[3ig3]] - mPLX-A3 intracellular domain<br />
 +
**[[5l5k]], [[5l5l]] – mPLX-A4 extracellular domain <br />
 +
**[[5l5k]] – mPLX-A4 extracellular domain segment 1-10<br />
 +
**[[5l5l]] – mPLX-A4 extracellular domain segment 1-8<br />
 +
**[[5l5m]], [[5l5n]] – mPLX-A4 extracellular domain segment 1-7<br />
**[[4e74]] - hPLX-A4 Rho GTPase-binding domain
**[[4e74]] - hPLX-A4 Rho GTPase-binding domain
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**[[2rex]] - hPLX-B1 effector domain + Rho-related GTP-binding protein Rho6
**[[2rex]] - hPLX-B1 effector domain + Rho-related GTP-binding protein Rho6
-
**[[2jph]] - hPLX-B1 Rho GTPase-binding domain – NMR<br />
+
**[[2jph]] - hPLX-B1 effector domain – NMR<br />
-
**[[4e71]] - hPLX-B2 Rho GTPase-binding domain<br />
+
**[[3ol2]] - hPLX-B1 + semaphorin 4D
**[[3ol2]] - hPLX-B1 + semaphorin 4D
**[[3sua]], [[3su8]] – hPLX-B1 + RAS-related C3 botulinum toxin substrate
**[[3sua]], [[3su8]] – hPLX-B1 + RAS-related C3 botulinum toxin substrate
-
**[[3hm6]] - hPLX-B1 cytoplasmic domain + peptide
+
**[[3hm6]] - hPLX-B1 cytoplasmic domain + peptide<br />
 +
**[[5b4w]] - hPLX-B1 residues 20-535 + peptide inhibitor<br />
 +
**[[4e71]] - hPLX-B2 effector domain<br />
 +
**[[5e6p]] - hPLX-B2 cytoplasmic domain + Rho guanine nucleotide exchange factor 11<br />
*Plexin C
*Plexin C
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*Plexin D
*Plexin D
-
**[[3h6n]] - hPLX-D1 ubiquitin-like domain
+
**[[3h6n]] - hPLX-D1 ubiquitin-like domain<br />
 +
**[[5v6r]] - mPLX-D1 intracellular domain <br />
 +
**[[5v6t]] - mPLX-D1 intracellular domain + GIPC1<br />
 +
 
}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 07:27, 12 September 2017

Glycosylated human plexin C1 (magenta) complex with semaphoric SEMA7A (green) and Ca+2 ion (green) (PDB entry 3nvn)

Drag the structure with the mouse to rotate

3D structures of plexin

12-September-2017

References

  1. ↑ Janssen BJ, Robinson RA, Perez-Branguli F, Bell CH, Mitchell KJ, Siebold C, Jones EY. Structural basis of semaphorin-plexin signalling. Nature. 2010 Sep 26. PMID:20877282 doi:10.1038/nature09468
  2. ↑ Winberg ML, Noordermeer JN, Tamagnone L, Comoglio PM, Spriggs MK, Tessier-Lavigne M, Goodman CS. Plexin A is a neuronal semaphorin receptor that controls axon guidance. Cell. 1998 Dec 23;95(7):903-16. PMID:9875845
  3. ↑ Perrot V, Vazquez-Prado J, Gutkind JS. Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF. J Biol Chem. 2002 Nov 8;277(45):43115-20. Epub 2002 Aug 14. PMID:12183458 doi:http://dx.doi.org/10.1074/jbc.M206005200

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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