5vh9
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of yeast cytoplasmic dynein-1 with Lis1 and ATP== | |
| - | + | <StructureSection load='5vh9' size='340' side='right' caption='[[5vh9]], [[Resolution|resolution]] 7.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5vh9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VH9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VH9 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5vlj|5vlj]]</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vh9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vh9 OCA], [http://pdbe.org/5vh9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vh9 RCSB], [http://www.ebi.ac.uk/pdbsum/5vh9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vh9 ProSAT]</span></td></tr> |
| - | [[Category: Leschziner, A | + | </table> |
| - | [[Category: Reck-Peterson, S | + | == Function == |
| - | [[Category: | + | [[http://www.uniprot.org/uniprot/DYHC_YEAST DYHC_YEAST]] Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required to maintain uniform nuclear distribution in hyphae. May play an important role in the proper orientation of the mitotic spindle into the budding daughter cell yeast. Probably required for normal progression of the cell cycle.<ref>PMID:15642746</ref> [[http://www.uniprot.org/uniprot/LIS1_YEAS7 LIS1_YEAS7]] Positively regulates the activity of the minus-end directed microtubule motor protein dynein. Plays a central role in positioning the mitotic spindle at the bud neck during cell division. Targets cytoplasmic dynein to microtubule plus ends, thereby promoting dynein-mediated microtubule sliding along the bud cortex and consequently the movement of the mitotic spindle to the bud neck. |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Cianfrocco, M A]] | ||
| + | [[Category: DeSantis, M E]] | ||
| + | [[Category: Htet, Z M]] | ||
| + | [[Category: Leschziner, A E]] | ||
| + | [[Category: Reck-Peterson, S L]] | ||
| + | [[Category: Tran, P T]] | ||
| + | [[Category: Cytoplasmic dynein]] | ||
| + | [[Category: Lis1]] | ||
| + | [[Category: Motor protein]] | ||
Revision as of 09:42, 13 September 2017
Cryo-EM structure of yeast cytoplasmic dynein-1 with Lis1 and ATP
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