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5gv2
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Arginine-bound CASTOR1 from Homo sapiens== | |
| - | + | <StructureSection load='5gv2' size='340' side='right' caption='[[5gv2]], [[Resolution|resolution]] 2.06Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5gv2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GV2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GV2 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5gv2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gv2 OCA], [http://pdbe.org/5gv2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gv2 RCSB], [http://www.ebi.ac.uk/pdbsum/5gv2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gv2 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/GATL3_HUMAN GATL3_HUMAN]] Functions as an intracellular arginine sensor that regulates the TORC1 signaling pathway through the GATOR complex. As a homooligomer or a heterooligomer with GATSL2, directly binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of arginine to GATSL3 disrupts the interaction of GATSL3-containing oligomers with GATOR2 and activates the TORC1 signaling pathway.<ref>PMID:26972053</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Gai, Z C]] | ||
[[Category: Wu, G]] | [[Category: Wu, G]] | ||
| - | [[Category: | + | [[Category: Arginine]] |
| + | [[Category: Castor1]] | ||
| + | [[Category: Dimer]] | ||
| + | [[Category: Signaling protein]] | ||
Revision as of 09:52, 13 September 2017
Crystal structure of Arginine-bound CASTOR1 from Homo sapiens
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Categories: Gai, Z C | Wu, G | Arginine | Castor1 | Dimer | Signaling protein
