5gv2

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'''Unreleased structure'''
 
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The entry 5gv2 is ON HOLD
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==Crystal structure of Arginine-bound CASTOR1 from Homo sapiens==
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<StructureSection load='5gv2' size='340' side='right' caption='[[5gv2]], [[Resolution|resolution]] 2.06&Aring;' scene=''>
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Authors: Gai, Z.C., Wu, G.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5gv2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GV2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GV2 FirstGlance]. <br>
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Description: Crystal structure of Arginine-bound CASTOR1 from Homo sapiens
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5gv2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gv2 OCA], [http://pdbe.org/5gv2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gv2 RCSB], [http://www.ebi.ac.uk/pdbsum/5gv2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gv2 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/GATL3_HUMAN GATL3_HUMAN]] Functions as an intracellular arginine sensor that regulates the TORC1 signaling pathway through the GATOR complex. As a homooligomer or a heterooligomer with GATSL2, directly binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of arginine to GATSL3 disrupts the interaction of GATSL3-containing oligomers with GATOR2 and activates the TORC1 signaling pathway.<ref>PMID:26972053</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Gai, Z C]]
[[Category: Wu, G]]
[[Category: Wu, G]]
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[[Category: Gai, Z.C]]
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[[Category: Arginine]]
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[[Category: Castor1]]
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[[Category: Dimer]]
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[[Category: Signaling protein]]

Revision as of 09:52, 13 September 2017

Crystal structure of Arginine-bound CASTOR1 from Homo sapiens

5gv2, resolution 2.06Å

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