5xjj
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of a MATE family protein== | |
| + | <StructureSection load='5xjj' size='340' side='right' caption='[[5xjj]], [[Resolution|resolution]] 2.90Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5xjj]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XJJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XJJ FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xjj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xjj OCA], [http://pdbe.org/5xjj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xjj RCSB], [http://www.ebi.ac.uk/pdbsum/5xjj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xjj ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The multidrug and toxic compound extrusion (MATE) family of proteins consists of transporters responsible for multidrug resistance in prokaryotes. In plants, a number of MATE proteins were identified by recent genomic and functional studies, which imply that the proteins have substrate-specific transport functions instead of multidrug extrusion. The three-dimensional structure of eukaryotic MATE proteins, including those of plants, has not been reported, preventing a better understanding of the molecular mechanism of these proteins. Here, we describe the crystal structure of a MATE protein from the plant Camelina sativa at 2.9 A resolution. Two sets of six transmembrane alpha helices, assembled pseudo-symmetrically, possess a negatively charged internal pocket with an outward-facing shape. The crystal structure provides insight into the diversity of plant MATE proteins and their substrate recognition and transport through the membrane. | ||
| - | + | Crystal Structure of a Plant Multidrug and Toxic Compound Extrusion Family Protein.,Tanaka Y, Iwaki S, Tsukazaki T Structure. 2017 Sep 5;25(9):1455-1460.e2. doi: 10.1016/j.str.2017.07.009. PMID:28877507<ref>PMID:28877507</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 5xjj" style="background-color:#fffaf0;"></div> | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Iwaki, S]] | [[Category: Iwaki, S]] | ||
[[Category: Tanaka, Y]] | [[Category: Tanaka, Y]] | ||
| + | [[Category: Tsukazaki, T]] | ||
| + | [[Category: Membrane protein]] | ||
| + | [[Category: Multidrug resistance]] | ||
| + | [[Category: Transport protein]] | ||
| + | [[Category: Transporter]] | ||
Revision as of 04:21, 21 September 2017
Crystal structure of a MATE family protein
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