Protein kinase Spk1

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Revision as of 16:24, 21 September 2017

Structure of yeast Rad53 FHA1 domain (cyan) complex with phosphothreonine peptide (green) (PDB code 1k3n).

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Updated on 21-September-2017

↑ Stern DF, Zheng P, Beidler DR, Zerillo C. Spk1, a new kinase from Saccharomyces cerevisiae, phosphorylates proteins on serine, threonine, and tyrosine. Mol Cell Biol. 1991 Feb;11(2):987-1001. PMID:1899289
↑ Yuan C, Yongkiettrakul S, Byeon IJ, Zhou S, Tsai MD. Solution structures of two FHA1-phosphothreonine peptide complexes provide insight into the structural basis of the ligand specificity of FHA1 from yeast Rad53. J Mol Biol. 2001 Nov 30;314(3):563-75. PMID:11846567 doi:10.1006/jmbi.2001.5140

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 *Rad53 FHA1 domain
-**[[1k3j]] – yRad53 FHA1 domain – yeast - NMR<br />
+**[[1k3j]] – yRad53 – yeast - NMR<br />
-**[[1g3g]], [[1j4o]] – yRad53 FHA1 domain (mutant) - NMR<br />
+**[[1g3g]], [[1j4o]] – yRad53 (mutant) - NMR<br />
-**[[1j4p]], [[1j4q]], [[1k3n]], [[1k3q]] – yRad53 FHA1 domain + Rad9 peptide - NMR<br />
+**[[1j4p]], [[1j4q]], [[1k3n]], [[1k3q]] – yRad53 + Rad9 peptide - NMR<br />
-**[[1g6g]], [[2a0t]] – yRad53 FHA1 domain + PTO peptide <br />
+**[[1g6g]], [[2a0t]] – yRad53 + PTO peptide <br />
-**[[2jqi]] – yRad53 FHA1 domain + PTO peptide - NMR<br />
+**[[2jqi]] – yRad53 + PTO peptide - NMR<br />
+**[[5t2f]] - yRad53/DBF4 BRCT domain<br />
+**[[5t2s]] - yRad53/DBF4 BRCT domain + phosphopeptide<br />
 *Rad53 FHA2 domain
-**[[1qu5]], [[1dmz]], [[1fhq]] – yRad53 FHA2 domain – yeast - NMR<br />
+**[[1qu5]], [[1dmz]], [[1fhq]] – yRad53 – yeast - NMR<br />
-**[[1fhr]], [[1j4k]], [[1j4l]], [[1k2m]], [[1k2n]] – yRad53 FHA2 domain + Rad9 peptide - NMR<br />
+**[[1fhr]], [[1j4k]], [[1j4l]], [[1k2m]], [[1k2n]] – yRad53 + Rad9 peptide - NMR<br />
 *Rad53 kinase and SCD2 domains