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Purine nucleoside phosphorylase
From Proteopedia
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| - | <StructureSection load=' | + | <StructureSection load='' size='450' side='right' caption='Human purine nucleoside phosphorylase complex with guanine and sulfate (PDB entry [[1v2h]])' scene='57/573714/Cv/1'> |
== Function == | == Function == | ||
'''Purine nucleoside phosphorylase''' (PNP) cleaves nucleosides by phosphorylating ribose to produce ribose-1-phosphate. PNP metabolizes adenosine, inosine and guanosine<ref>PMID:11337031</ref>. PNP metabolizes the waste molecules deoxyinosine and deoxyguanosine which are formed when DNA breaks down. | '''Purine nucleoside phosphorylase''' (PNP) cleaves nucleosides by phosphorylating ribose to produce ribose-1-phosphate. PNP metabolizes adenosine, inosine and guanosine<ref>PMID:11337031</ref>. PNP metabolizes the waste molecules deoxyinosine and deoxyguanosine which are formed when DNA breaks down. | ||
Revision as of 14:06, 23 September 2017
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3D structures of purine nucleoside phosphorylase
Updated on 23-September-2017
References
- ↑ Bzowska A, Kulikowska E, Shugar D. Purine nucleoside phosphorylases: properties, functions, and clinical aspects. Pharmacol Ther. 2000 Dec;88(3):349-425. PMID:11337031
- ↑ Markert ML. Purine nucleoside phosphorylase deficiency. Immunodefic Rev. 1991;3(1):45-81. PMID:1931007
- ↑ de Azevedo WF Jr, Canduri F, dos Santos DM, Pereira JH, Bertacine Dias MV, Silva RG, Mendes MA, Basso LA, Palma MS, Santos DS. Crystal structure of human PNP complexed with guanine. Biochem Biophys Res Commun. 2003 Dec 19;312(3):767-72. PMID:14680831 doi:10.1016/j.bbrc.2003.10.190
