Response regulator

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'''Response regulators''' (RR) are part of the two-component signal transduction systems which enable bacteria to sense and respond to a wide range of environments.
'''Response regulators''' (RR) are part of the two-component signal transduction systems which enable bacteria to sense and respond to a wide range of environments.
-
Two-component RR is a complex of histidine kinase (sensor protein SP) and RR. The RR act as phosphorylation-activated switches. Most RR consist of N terminal which is the signal receiving domain and C terminal which is the DNA-binding domain.
+
Two-component RR is a complex of histidine kinase (sensor protein SP) and RR. The RR act as phosphorylation-activated switches. Most RR consist of N terminal which is the signal receiving domain and C terminal which is the DNA-binding domain (DBD).
*'''RR CheY''' is a chemotaxis response regulator in bacteria<ref>PMID:14563873</ref>. <br />
*'''RR CheY''' is a chemotaxis response regulator in bacteria<ref>PMID:14563873</ref>. <br />
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**[[2qsj]] – LuxR – ''Silicibbacter pomeroyi''<br/ >
**[[2qsj]] – LuxR – ''Silicibbacter pomeroyi''<br/ >
**[[3cnb]], [[3eqz]] – MerR receiver domain – ''Colwellia psychrerythraea''<br/ >
**[[3cnb]], [[3eqz]] – MerR receiver domain – ''Colwellia psychrerythraea''<br/ >
-
**[[2rnj]] – SaVraR DNA-binding domain – ''Staphylococcus aureus'' – NMR<br/ >
+
**[[2rnj]] – SaVraR DBD – ''Staphylococcus aureus'' – NMR<br/ >
-
**[[2zxj]] - SaWalR DNA-binding domain<br/ >
+
**[[2zxj]] - SaWalR DBD<br/ >
**[[4gvp]] – SaVraR<br />
**[[4gvp]] – SaVraR<br />
**[[4if4]] – SaVraR + Mg + BeF3<br />
**[[4if4]] – SaVraR + Mg + BeF3<br />
**[[3q9s]] – DrRR receiver domain – ''Deinococcus radiodurans''<br/ >
**[[3q9s]] – DrRR receiver domain – ''Deinococcus radiodurans''<br/ >
**[[3q9v]] - DrRR C terminal<br />
**[[3q9v]] - DrRR C terminal<br />
-
**[[3rjp]] - RR DNA -binding domain – ''Streptococcus pyogenes''<br />
+
**[[3rjp]] - RR DBD – ''Streptococcus pyogenes''<br />
**[[2a9r]] – SpRR N terminal + phosphate + Mg
**[[2a9r]] – SpRR N terminal + phosphate + Mg
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**[[1mvo]] – BsPhoP receiver domain<br/ >
**[[1mvo]] – BsPhoP receiver domain<br/ >
**[[2jb9]], [[2jba]] – EcPhoB (mutant) <br/ >
**[[2jb9]], [[2jba]] – EcPhoB (mutant) <br/ >
-
**[[2pmu]] – MtPhoP DNA-binding domain
+
**[[2pmu]] – MtPhoP DBD
*Polar differentiation response regulator
*Polar differentiation response regulator
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*Photosynthetic apparatus response regulator
*Photosynthetic apparatus response regulator
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**[[1umq]] – PrrA DNA-binding domain – ''Rhodobacter sphaeroides'' – NMR<br/ >
+
**[[1umq]] – PrrA DBD – ''Rhodobacter sphaeroides'' – NMR<br/ >
**[[1ys6]] – MtPrrA <br/ >
**[[1ys6]] – MtPrrA <br/ >
**[[1ys7]] – MtPrrA + Mg
**[[1ys7]] – MtPrrA + Mg
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**[[1xhe]] – EcArcA receiver domain <br/ >
**[[1xhe]] – EcArcA receiver domain <br/ >
**[[1xhf]] – EcArcA receiver domain + BeF3<BR/ >
**[[1xhf]] – EcArcA receiver domain + BeF3<BR/ >
 +
**[[4ynr]] - MtDevs GAF domain + CO<br />
 +
**[[4yof]] - MtDevs GAF domain + NO<br />
**[[2y79]] – MtDevs GAF domain (mutant)<br />
**[[2y79]] – MtDevs GAF domain (mutant)<br />
**[[3zxo]] - MtDevs ATP-binding domain (mutant)<br />
**[[3zxo]] - MtDevs ATP-binding domain (mutant)<br />
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**[[2zwm]] – BsYycF receiver domain<br/ >
**[[2zwm]] – BsYycF receiver domain<br/ >
-
**[[3ulq]] – BsComA DNA-binding domain + RR aspartate phosphatase<br />
+
**[[5iuj]], [[5iuk]], [[5iul]], [[5iun]] - BsDesR + DesK<br />
 +
**[[3ulq]] – BsComA DBD + RR aspartate phosphatase<br />
**[[2pkx]] – EcPhoP regulatory domain<br />
**[[2pkx]] – EcPhoP regulatory domain<br />
 +
**[[5ed4]] - MtPhoP + DNA<br />
**[[3nhz]] – MtMtra N terminal<br />
**[[3nhz]] – MtMtra N terminal<br />
 +
**[[5fmn]] - SyInrS<br />
 +
**[[5lwk]] - LpMaeR + BeF3 - ''Lactobacillus paracasei''<br />
 +
**[[5lwl]] - LpMaeR (mutant)<br />
 +
**[[4g9y]] - ScPcaV - ''Streptomyces coelicolor''<br />
 +
**[[4fht]] - ScPcaV + hydroxybenzoic acid<br />
 +
**[[4u88]] - SaSaeR DBD<br />
 +
**[[4ixa]] - SaeR DBD - ''Staphylococcus epidermidis''<br />
 +
**[[4so5]] - BasR + DNA - ''Klebsiella pneumoniae''<br />
*Stress response regulator
*Stress response regulator
-
**[[3n0r]] – CVPhyR
+
**[[3n0r]] – CVPhyR<br />
 +
**[[5i4c]] - EcRcsB receiver domain<br />
 +
**[[3cra]], [[3crc]] - EcMazG<br />
 +
**[[2v42]], [[2v43]] - EcRseB<br />
-
*Chemotaxis response regulator
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*Chemotaxis response regulator see [[Chemotaxix protein]]
-
 
+
-
**[[3t8y]] - EcCheB<br />
+
-
**[[1mih]], [[1jbe]] – EcCheY<br />
+
-
**[[1p6q]] – SmCheY2 - ''Sinorhizobium meliloti''<br />
+
-
**[[1p6u]] – SmCheY2 + BeF3<br />
+
-
**[[3hzh]] – CheY-3 + CheX – ''Borrelia burgdorferi''<br />
+
-
**[[1u0s]] – TmCheY + CheA<br />
+
-
**[[2chy]] – CheY – ''Salmonella typhimurium''
+
-
 
+
-
*CheY-like response regulator
+
-
 
+
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**[[3snk]] – RR – ''Mesorhizobium loti''<br/ >
+
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**[[3cg4]], [[3crn]] - RR receiver domain – ''Methanospirillum hungatei''<br/ >
+
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**[[3i42]] – RR receiver domain – ''Methylobacter flagellates''<br />
+
-
**[[3bre]] – PaRR – ''Pseudomonas aeruginosa''<br/ >
+
*Two-component response regulator
*Two-component response regulator
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**[[2qr3]] – RR N terminal – ''Bacteroides fragilis''<br />
**[[2qr3]] – RR N terminal – ''Bacteroides fragilis''<br />
**[[2qzj]] – RR – ''Clostridium difficile''<br />
**[[2qzj]] – RR – ''Clostridium difficile''<br />
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**[[3cz5]] – RR – ''Aurantimonas''
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**[[3cz5]] – RR – ''Aurantimonas''<br />
 +
**[[2qvg]] - RR - ''Legionella pneumophila''<br />
 +
**[[3ilh]] - RR - ''Cytophaga hutchinsonii''<br />
 +
**[[5brj]] - RR - ''Agrobacterium tumefaciens''<br />
 +
**[[5uic]] - QseB - ''Francisella tularensis''<br />
 +
**[[3lsg]] - RR C-terminal - ''Fusobacterium nucleatum''<br />
 +
**[[3p01]] - RR - Nostoc<br />
*response regulator receiver domain protein
*response regulator receiver domain protein

Revision as of 20:19, 25 September 2017

Se-Met DNA-binding response regulator D complex with thiocyanate, 1kgs

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3D Structures of response regulator

Updated on 25-September-2017

References

  1. ↑ Smith JG, Latiolais JA, Guanga GP, Citineni S, Silversmith RE, Bourret RB. Investigation of the role of electrostatic charge in activation of the Escherichia coli response regulator CheY. J Bacteriol. 2003 Nov;185(21):6385-91. PMID:14563873
  2. ↑ Ladds JC, Muchova K, Blaskovic D, Lewis RJ, Brannigan JA, Wilkinson AJ, Barak I. The response regulator Spo0A from Bacillus subtilis is efficiently phosphorylated in Escherichia coli. FEMS Microbiol Lett. 2003 Jun 27;223(2):153-7. PMID:12829280
  3. ↑ Hecht GB, Newton A. Identification of a novel response regulator required for the swarmer-to-stalked-cell transition in Caulobacter crescentus. J Bacteriol. 1995 Nov;177(21):6223-9. PMID:7592388
  4. ↑ Menon S, Wang S. Structure of the Response Regulator PhoP from Mycobacterium tuberculosis Reveals a Dimer through the Receiver Domain. Biochemistry. 2011 Jul 5;50(26):5948-57. Epub 2011 Jun 13. PMID:21634789 doi:10.1021/bi2005575
  5. ↑ Eraso JM, Kaplan S. Complex regulatory activities associated with the histidine kinase PrrB in expression of photosynthesis genes in Rhodobacter sphaeroides 2.4.1. J Bacteriol. 1996 Dec;178(24):7037-46. PMID:8955382
  6. ↑ Malone JG, Williams R, Christen M, Jenal U, Spiers AJ, Rainey PB. The structure-function relationship of WspR, a Pseudomonas fluorescens response regulator with a GGDEF output domain. Microbiology. 2007 Apr;153(Pt 4):980-94. PMID:17379708 doi:http://dx.doi.org/10.1099/mic.0.2006/002824-0
  7. ↑ Allen JF. Redox control of transcription: sensors, response regulators, activators and repressors. FEBS Lett. 1993 Oct 18;332(3):203-7. PMID:8405457

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