1x9p
From Proteopedia
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|PDB= 1x9p |SIZE=350|CAPTION= <scene name='initialview01'>1x9p</scene>, resolution 3.30Å | |PDB= 1x9p |SIZE=350|CAPTION= <scene name='initialview01'>1x9p</scene>, resolution 3.30Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= | + | |LIGAND= <scene name='pdbligand=C15:N-DODECYL-N,N-DIMETHYL-3-AMMONIO-1-PROPANESULFONATE'>C15</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= penton base ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10515 Human adenovirus 2]) | |GENE= penton base ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10515 Human adenovirus 2]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1x9t|1X9T]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1x9p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x9p OCA], [http://www.ebi.ac.uk/pdbsum/1x9p PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1x9p RCSB]</span> | ||
}} | }} | ||
| Line 26: | Line 29: | ||
[[Category: Schoehn, G.]] | [[Category: Schoehn, G.]] | ||
[[Category: Zubieta, C.]] | [[Category: Zubieta, C.]] | ||
| - | [[Category: C15]] | ||
| - | [[Category: SO4]] | ||
[[Category: anti-parallel beta sheet]] | [[Category: anti-parallel beta sheet]] | ||
[[Category: insertion domain]] | [[Category: insertion domain]] | ||
[[Category: jellyroll domain]] | [[Category: jellyroll domain]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:46:37 2008'' |
Revision as of 21:46, 30 March 2008
| |||||||
| , resolution 3.30Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||
| Gene: | penton base (Human adenovirus 2) | ||||||
| Related: | 1X9T
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
The crystal structure of human adenovirus 2 penton base
Overview
The adenovirus penton, a noncovalent complex of the pentameric penton base and trimeric fiber proteins, comprises the vertices of the adenovirus capsid and contains all necessary components for viral attachment and internalization. The 3.3 A resolution crystal structure of human adenovirus 2 (hAd2) penton base shows that the monomer has a basal jellyroll domain and a distal irregular domain formed by two long insertions, a similar topology to the adenovirus hexon. The Arg-Gly-Asp (RGD) motif, required for interactions with cellular integrins, occurs on a flexible surface loop. The complex of penton base with bound N-terminal fiber peptide, determined at 3.5 A resolution, shows that the universal fiber motif FNPVYPY binds at the interface of adjacent penton base monomers and results in a localized structural rearrangement in the insertion domain of the penton base. These results give insight into the structure and assembly of the adenovirus capsid and will be of use for gene-therapy applications.
About this Structure
1X9P is a Single protein structure of sequence from Human adenovirus 2. Full crystallographic information is available from OCA.
Reference
The structure of the human adenovirus 2 penton., Zubieta C, Schoehn G, Chroboczek J, Cusack S, Mol Cell. 2005 Jan 7;17(1):121-35. PMID:15629723
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