1xod
From Proteopedia
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|ACTIVITY= | |ACTIVITY= | ||
|GENE= Spred1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8364 Xenopus tropicalis]) | |GENE= Spred1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8364 Xenopus tropicalis]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xod OCA], [http://www.ebi.ac.uk/pdbsum/1xod PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1xod RCSB]</span> | ||
}} | }} | ||
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[[Category: Harmer, N J.]] | [[Category: Harmer, N J.]] | ||
[[Category: Sivak, J M.]] | [[Category: Sivak, J M.]] | ||
| - | [[Category: GOL]] | ||
[[Category: evh1]] | [[Category: evh1]] | ||
[[Category: peptide-binding]] | [[Category: peptide-binding]] | ||
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[[Category: sprouty]] | [[Category: sprouty]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:52:26 2008'' |
Revision as of 21:52, 30 March 2008
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| , resolution 1.15Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | Spred1 (Xenopus tropicalis) | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of X. tropicalis Spred1 EVH-1 domain
Overview
The recently described Spred protein family has been implicated in the modulation of receptor tyrosine kinase signalling. We report the crystal structure of the Enabled/vasodilator-stimulated phosphoprotein homology-1 (EVH1) domain from Xenopus tropicalis Spred1, solved to 1.15 A resolution. This structure confirms that the Spred EVH1 adopts the pleckstrin-homology fold, with a similar secondary structure to Enabled. A translation of one of the peptide-binding groove beta-strands narrows this groove, whilst one end of the groove shows structural flexibility. We propose that Spred1 will bind peptides that are less proline-rich than other EVH1 domains, with conformational changes indicating an induced fit.
About this Structure
1XOD is a Single protein structure of sequence from Xenopus tropicalis. Full crystallographic information is available from OCA.
Reference
1.15 A crystal structure of the X. tropicalis Spred1 EVH1 domain suggests a fourth distinct peptide-binding mechanism within the EVH1 family., Harmer NJ, Sivak JM, Amaya E, Blundell TL, FEBS Lett. 2005 Feb 14;579(5):1161-6. PMID:15710406
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