1xzz
From Proteopedia
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|ACTIVITY= | |ACTIVITY= | ||
|GENE= Itpr1, Insp3r, Pcd6, Pcp1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]) | |GENE= Itpr1, Insp3r, Pcd6, Pcp1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xzz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xzz OCA], [http://www.ebi.ac.uk/pdbsum/1xzz PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1xzz RCSB]</span> | ||
}} | }} | ||
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[[Category: Mikoshiba, K.]] | [[Category: Mikoshiba, K.]] | ||
[[Category: Yamazaki, H.]] | [[Category: Yamazaki, H.]] | ||
| - | [[Category: GOL]] | ||
[[Category: b-trefoil fold]] | [[Category: b-trefoil fold]] | ||
[[Category: calcium channel]] | [[Category: calcium channel]] | ||
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[[Category: ip3 receptor suppressor domain]] | [[Category: ip3 receptor suppressor domain]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:56:58 2008'' |
Revision as of 21:57, 30 March 2008
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| , resolution 1.80Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | Itpr1, Insp3r, Pcd6, Pcp1 (Mus musculus) | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of the ligand binding suppressor domain of type 1 inositol 1,4,5-trisphosphate receptor
Overview
Binding of inositol 1,4,5-trisphosphate (IP(3)) to the amino-terminal region of IP(3) receptor promotes Ca(2+) release from the endoplasmic reticulum. Within the amino terminus, the first 220 residues directly preceding the IP(3) binding core domain play a key role in IP(3) binding suppression and regulatory protein interaction. Here we present a crystal structure of the suppressor domain of the mouse type 1 IP(3) receptor at 1.8 A. Displaying a shape akin to a hammer, the suppressor region contains a Head subdomain forming the beta-trefoil fold and an Arm subdomain possessing a helix-turn-helix structure. The conserved region on the Head subdomain appeared to interact with the IP(3) binding core domain and is in close proximity to the previously proposed binding sites of Homer, RACK1, calmodulin, and CaBP1. The present study sheds light onto the mechanism underlying the receptor's sensitivity to the ligand and its communication with cellular signaling proteins.
About this Structure
1XZZ is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
Crystal structure of the ligand binding suppressor domain of type 1 inositol 1,4,5-trisphosphate receptor., Bosanac I, Yamazaki H, Matsu-Ura T, Michikawa T, Mikoshiba K, Ikura M, Mol Cell. 2005 Jan 21;17(2):193-203. PMID:15664189
Page seeded by OCA on Mon Mar 31 00:56:58 2008
