Rho GTPase

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Line 23: Line 23:
**[[5ez6]], [[5c4m]], [[5a0f]], [[1dpf]], [[1ftn]] – hRhoA + GDP – human<br />
**[[5ez6]], [[5c4m]], [[5a0f]], [[1dpf]], [[1ftn]] – hRhoA + GDP – human<br />
 +
**[[5a0f]] - hRhoA (mutant) + GDP<br />
**[[1kmq]] – hRhoA (mutant) + GNP<br />
**[[1kmq]] – hRhoA (mutant) + GNP<br />
**[[1a2b]] – hRhoA + GSP<br />
**[[1a2b]] – hRhoA + GSP<br />
Line 30: Line 31:
**[[4xh9]] – hRhoA (mutant) + guanine nucleotide exchange factor NET1<br />
**[[4xh9]] – hRhoA (mutant) + guanine nucleotide exchange factor NET1<br />
 +
**[[5jhg]], [[5jhh]] - hRhoA + guanine nucleotide exchange factor 11<br />
**[[3t06]], [[1xcg]] – hRhoA (mutant) + guanine nucleotide exchange factor 11<br />
**[[3t06]], [[1xcg]] – hRhoA (mutant) + guanine nucleotide exchange factor 11<br />
**[[1lb1]] – hRhoA (mutant) + guanine nucleotide exchange factor Dbs<br />
**[[1lb1]] – hRhoA (mutant) + guanine nucleotide exchange factor Dbs<br />
Line 38: Line 40:
**[[5irc]] – hRhoA + Rho GTPase-activating protein 20 + GDP <br />
**[[5irc]] – hRhoA + Rho GTPase-activating protein 20 + GDP <br />
-
**[[1ow3]] – hRhoA + Rho GTPase-activating protein 1 + GDP <br />
+
**[[1ow3]], [[5m6x]], [[5m70]] – hRhoA + Rho GTPase-activating protein 1 + GDP <br />
**[[3msx]] – hRhoA (mutant) + Rho GTPase-activating protein 35 + GDP <br />
**[[3msx]] – hRhoA (mutant) + Rho GTPase-activating protein 35 + GDP <br />

Revision as of 17:57, 27 September 2017

Human RhoA (magenta) complex with RhoGAP (cyan), GDP, AlF4 and Mg+2 ion (green) (PDB code 1tx4)

Drag the structure with the mouse to rotate

3D structures of Rho GTPase

Updated on 27-September-2017

References

  1. Sepp KJ, Auld VJ. RhoA and Rac1 GTPases mediate the dynamic rearrangement of actin in peripheral glia. Development. 2003 May;130(9):1825-35. PMID:12642488
  2. Fransson A, Ruusala A, Aspenstrom P. Atypical Rho GTPases have roles in mitochondrial homeostasis and apoptosis. J Biol Chem. 2003 Feb 21;278(8):6495-502. Epub 2002 Dec 12. PMID:12482879 doi:http://dx.doi.org/10.1074/jbc.M208609200
  3. Zhou J, Hayakawa Y, Wang TC, Bass AJ. RhoA mutations identified in diffuse gastric cancer. Cancer Cell. 2014 Jul 14;26(1):9-11. doi: 10.1016/j.ccr.2014.06.022. PMID:25026207 doi:http://dx.doi.org/10.1016/j.ccr.2014.06.022
  4. Jin L, Burnett AL. RhoA/Rho-kinase in erectile tissue: mechanisms of disease and therapeutic insights. Clin Sci (Lond). 2006 Feb;110(2):153-65. PMID:16411892 doi:http://dx.doi.org/10.1042/CS20050255
  5. Rittinger K, Walker PA, Eccleston JF, Smerdon SJ, Gamblin SJ. Structure at 1.65 A of RhoA and its GTPase-activating protein in complex with a transition-state analogue. Nature. 1997 Oct 16;389(6652):758-62. PMID:9338791 doi:10.1038/39651

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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